I think it could be done, but I have only managed islands and contients. It has been a long time since I tried a pangea though.
The killer is they will have contacts very fast as they start with 12 warriors or archers and 6 defenders. Expansionist have scouts and soon all will have met and traded techs and the tech race will ignite.
You will have a hard time getting the GL and an even harder time keeping it. The way you get it now is to get to lit first and get a jump. On pangea you will probably not be first to lit.
Next you will find them at least one age ahead and probably more. This can get ugly as they pay 40% for things. It is a real pain to play on huge maps with so many units flying around. I have not been able to talk myself into. Contients was plenty of work.
The one saving grace I see is that at least they will likely have some wars, but that can be a double edged sword. The good is they can slow each other down. The bad is they could take one or the other down and gain more land.
Also they will not be pressing their support limits as much and will be able to research faster, all bad.