One thing to consider, though, is that if you lock yourself out of worldbuilder then you make it impossible to recover from a variety of problems. The mod is not totally devoid of bugs, and some of these can be worked around by careful worldbuilder editing. I always played with assets locked before I started FfH2, but now I never do. If you're not inclined to mess with worldbuilder to try to fix a problem or don't mind abandoning a bugged game then there's probably no harm in locking your game.