IMHO I would still follow the academic practice and put the end of Early Modern at the French Revolution. The Age of Revolution (1775/1789-1815/1848) very much destroyed the absolute monarchy which was a dominate feature in the Early Modern Era.
Not just politics. The French Revolution started about money: the French monarchy trying to extract more of it from their French subjects but limiting the extraction to non-aristocratic, non-religious sources and discovering that those sources objected strenuously and murderously to that. But that, in turn, was because the sources of wealth in the state had already changed dramatically: the French aristocracy, in fact, was virtually impoverished as a Class by 1789 because money now came from commerce and manufacturing, not Land. Cue the economic revolution, which was already well along all over western Europe.
And the period 1789 - 1815 was a watershed in manufacturing techniques. In 1800 Maudslay invented the screw-cutting lathe which, for the first time, allowed parts to be made by machine that were
exactly identical: cue really Interchangeable Parts. 5 years later Brunel and Maudslay introduced mass-production of pulley blocks in the Royal Dockyards for the British Navy by specialized purpose-built machinery: from there to Ford's factories turning out a Model T automobile every few minutes is just refining the technique over the next century.
And finally, ALL modern armies have the same structure as the armies of Revolutionary France and her enemies: regiments and brigades in divisions under Corps HQ and Armies composed of several Corps. The only thing that has been added is the Army Group once forces went beyond a million men in a single campaign. Even basic military staff work today, though electronically mechanized, is based on the principles established by Berthier for Napoleon's
Grande Armee.
The changes were continuous, but by 1815 not only was the legitimacy of all monarchies in serious question, but also all traditional manufacturing, economic, and military techniques and practices were being replaced by entirely new technologies and their consequences.
Railroads could not have been built at all with the manufacturing and financial mechanisms of the 18th century.
The armies of the US Civil War (1861 - 65) or the Franco-Prussian War (1870 - 1871) could not have been moved, controlled, or supplied with weapons and ammunition without the changes in industry and military staffing and control introduced between 1789 and 1815.
No machinery could have been applied to 'mass production' without the changes in precision introduced between 1800 and 1805 and developed further in the following years. The Real "Industrial Revolution" starts in 1800: everything before that was just preliminaries.
BUT
My problem with "Eras" as they are being used in both Civ and
Humankind is that no Era ever changed the same way in all parts of the world. The "Medieval" Era was indeed very different from early to late timeframe - in Europe and China, but not so much in India, Africa, or the Americas.
1492 and the "Columbian Exchange" that followed did have massive effects all over the world, but one of those effects was the extermination of up to 90% of the native population of the Americas by introduced diseases, an effect that no one has ever suggested trying to replicate in a game!