I do have quite a big handicap actually, I start on the rather dry deserty arabian pennisula, expansion west is blocked by egypt, expansion east by persia, north by ottomans, and south (east coast of africa) by water and the zulu. I will very likely be boxed in quite early. Also the one special resource I have in abundance (oil) is not available until very late in the game. In my situation knowledge of the map won't help me because the big advantage of knowing the map is knowing where the settlable islands are but my location is too far from any of them to help me. Also there are no goodie huts. Another thing it is a big map so after some time of playing I will have probably have forgotten where all the unrevealed resources are.
If you think that is not sufficient a handicap then how about I be the only civ that can't declare war for the first 40 turns (but anyone can declare war on me)?