Alvaro da Luna
Warlord
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- Jan 28, 2004
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Inspired by the strep throat thread.
Inspired by the strep throat thread.
Strep Link To Obsessive-compulsive Disorder
NEW YORK (Reuters) -- Strep throat may trigger some cases of childhood obsessive-compulsive disorder (OCD), reported researchers from National Institutes of Mental Health (NIMH) at an American Medical Association (AMA) press conference.
"A bacteria trigger for an autoimmune response" can lead to a worsening of obsessive-compulsive disorder, reported Dr. Susan E. Swedo, head of the section on behavioral pediatrics at the NIMH. "Penicillin... to keep these children from having recurrent strep infections might effectively prevent exacerbations of their obsessive-compulsive disorder," she said.
As part of the defense against bacteria, the body creates antibodies to act against specific proteins on the surface of bacteria. However, sometimes bacteria carry proteins that are very similar to cells in the body. An autoimmune disorder results when the immune system mistakenly attacks healthy tissue in its fight against infection.
In the case of OCD, the strep bacteria are believed to have surface proteins that mimic proteins on brain cells. The result: antibodies the body makes against strep bacteria may also attack brain tissue.
Affected children "are characterized by an extraordinarily early onset of their symptoms -- they're only 6 or 7 years old when their OCD starts -- (and) they tend to be boys about three times as often as girls," said Swedo. A strep infection can cause a sudden worsening of OCD in children with the disorder, or precipitate the first signs of OCD. And a flare up can occur the next time the children are exposed to the strep bacteria.
"There is growing evidence that OCD has a neurobiological basis," according to a statement from the National Institutes of Health. "OCD is no longer attributed to family problems or to attitudes learned in childhood -- for example, an inordinate emphasis on cleanliness.... Instead, the search for causes now focuses on the interaction of neurobiological factors and environmental influences."
Symptoms of OCD include intrusive unwanted thoughts and repeated rituals such as excessive handwashing, checking or cleaning designed to alleviate these thoughts. The most common fears found among OCD patients are fear of contamination, fear of causing harm, fear of making a mistake, and excessive doubt.
Studies show antidepressants in combination with cognitive behavior therapy can decrease symptoms of this disorder.
Swedo said that OCD is a "hidden epidemic." Feelings of embarrassment and knowledge of their irrational state force most patients to live an average of 17 years with the symptoms before seeking a diagnosis, Swedo added.
According to the National Institutes of Health, approximately 5 million Americans suffer from OCD -- or about 1 in every 50 people. The disorder usually begins during childhood or early adolescence. In 1990, OCD cost the U.S. $8.4 billion in social and economic costs.