Holmes County, Ohio, is an interesting county. It is, AFAIK, the most Amish county in Ohio. Horses and buggies are very common up there, as are e-bikes, which are more common among the Amish than among the English (non-Amish).
Rural Mississippi is actually fairly diverse politically. Holmes County, Mississippi
voted over 80% Democratic in 2024. Many of the Delta counties are Democratic, and many of them are also among the poorest. Generally, the poorer, as well as the more African-American, the more Democratic the county is.
Of course it can swing the other way too. I've been to Hinds County, MS (73% Democratic, urban) and Jeff Davis County, MS (57% Democratic, rural), but also Pontotoc County (84% Republican, suburban/rural) and Lee County (70% Republican, urban) [all stats are 2024 U.S. presidential]. At a state government level, the Republicans have been in charge for a while, but at a local level, it's perhaps more diverse than most places. You won't find a rural Democratic county in Ohio, for example, even if the overall state balance might be closer to 50:50.
Not saying it would be my first choice, the poverty can be quite noticeable in some areas, and it would be hot and humid in the summer (the primary reason I'd prefer somewhere farther north), but you could probably find a neighborhood that you agreed with politically regardless of what your political beliefs or rural/urban preferences were.