Too much of a warmonger and too low difficulty to get that late in the game.
But from videos I've seen difficulty is relevant, toying around on emperor like me and you are probably fine, on diety the AI builds sooooo many units that late game CTDs sometimes seems inevitable.
Mapsize matters and ofc additional mods.
Ohh, that's a very good point about more units in Deity.
I am one of the few lucky people who almost never experience CTDs. Neither on my older, but powerful laptop, nor on my newer, but less powerful one.
Although I get a lot of throttling on my less powerful machine after a few turns in later eras. I click a unit, I can issue commands by right click or by using hotkeys, and it does what I command, but the UI focus is still on the previous unit, sometimes for 10 secs or more, which is annoying. Same for the cities, they display the build queue and specialists for the previous city for several seconds What helps is switching to the strategic view and back, or restarting the game when it gets unbearable. I think it's something to do with the graphics, my GPU is quite a weak one.
I usually play until turn 600-700 on huge, epic, with a ton of extra mods, adding about 10 extra units.
I kill several hungry processes before starting Civ5 and I turn off the FOW clouds, shadows and animated oceans. So not the lowest settings.
Also, on my older, but more powerful laptop, I was getting completely stuck and unresponsive screen (but the game was running in the background, I could hear the sounds when issuing commands to units or clicking, etc.), if I was using Ethnic Units. Roughly from Industrial era. Removing Ethnic Units fixed it.