I rarely use it.
I didn't pay $50 to play a more complex version of Settlers of Cataan
Do you have High Detail Strategic view enabled? I find it very aesthetically pleasing, almost like looking at stained glass, but not quite. Try using it for the first 50-100 turns exclusively. I assure you, it becomes a lot easier to figure out that way and afterward you can hit F10 and tell at a glance what is going on.
The only time I don't is when one of my units gets stuck in a city (bug?), and clicking on it won't let me select it. I have to switch to 3D in order to get it out.
I've tried it with and without, and can't say I've noticed it looking any different.