Well we finally had an OOS in our games, I am not sure, however, if it is significant in the long run. We had our game where we added Hyborem and Basium and put the counter on "last days" just for the hell of it and had no problems until turn 386.
UNIQUE FEATURES OF OUR GAME:
Small Map (Highlands)
events (disabled)
last days (enabled)
CIVS: Hannah (human), Dain, Tebryn, Mahala, Perpentach, Sabathiel (human), Garrim Gyr and Einon Logos
1. On the turn of said OOS, the counter had not gone up or down (so far as we know)
2. There were no other events or special buildings/units completed that we know of, but of course we can't see everything...
3. Basium and Hyborem had not yet entered the game, but on turn 386 when it went out of sync the only thing that we DID notice was that Einon Logos had cast his world spell, Sanctuary, which moved a lot of units out of his lands.
We reloaded an autosave, and on the same turn he didn't cast Sanctuary, and yet it still went OOS a few turns later. So maybe Sanctuary has nothing to do with it.
NOTE: Then the next time we loaded the save of turn 386 where the OOS occurred the game did not go OOS. I don't know if this is significant, but after this we continued to play for another 130 turns but the lag between turns rose to about 20-30 seconds of wait time and the game became extremely sluggish. Considering that we are both on higher end machines this should not have been an issue, and wasn't before the OOS.