Sorry for a what-if? question that so many people seem to detest here, but this one always keeps me wondering. Without the many diseases that killed off much of the Native Americans, making it much easier for Europeans to take over the Americas, do you think that the Native Americans could have resisted? Perhaps the Native Americans even had fully developed empires and complex societies, only to collapse because of the plague. There's evidence of farming in the Great Plains, where the Europeans discovered Native American Nomads. Who knows what kind of society the Europeans missed? The US might have never formed!