Like to know about the DRM (the minute I hear the words "Securom" or "rootkit" or anything like that, count me out). Some DRM is ok. Nothing inconvenient or dangerous, though.
The Panzer General thing. I'm certainly not opposed to some wargame influence (slumming it with PG - bit too common for me, but ok), but I really need to know more about how the mechanics of a tactical game that usually represents an area about 50-100 miles across is going to be translated into a strategic game that represents a planetary area.
Moddability. It's getting easier to describe what you can't change rather than what you can, so this is what I'd like to know. Also, how modding is different from civ4. Not so much the graphics formats, but I'd like to know if modding will essentially be different from the current mix of xml, Python, and the DLL. Vanilla mechanics are not all that crucial, except the things that can't be changed, or the things that are more difficult to change (eg what has to be modded in the DLL).
A little bit more about "social policies". Can they be switched, or are these really just glorified traits that you're stuck with for the rest of the game? I'm thinking dropping civics might be a huge mistake - it was definately one of the better new ideas in civ4, and allowed for alot of variety in play style. I'm not sure how many possible combinations there were but it was a heck of alot more than four! Most of the other changes/reversions are neutral/good/not that big of a loss, but I'm concerned about this one.