Looking at the map of your continent, it seems like the civs proceed like this:
HRE -> England -> Maya
with Sitting Bull not even on your continent.
I say you use Isabella for a succession of crusades. First, ensure that the HRE is neither Holy, nor Roman, nor an Empire by wiping it out. Then, get Pacal and Sitting Bull on the same page, religion-wise. Make sure that Lizzie is *not* on that same page. Build the AP. Declare war on heathen Elizabeth and build a new Jerusalem on England's green and pleasant land. Lizzie's now getting it from both ends, er, border-wise. She may fight you on the beaches, etc, but she'll fall.
Now you've got you, Pacal and Sitting Bull. If you're daring, you can try the same thing all over again with Pacal. Get him to convert to something else. You and Sitting Bull declare. Lather, rinse, repeat. To get this done, I'd recommend not overly spreading your religion from Continental War I. Perhaps let Pacal maintain his Buddhism, while converting (barely) Sitting Bull. Once you're ready for Continental War II, convert to Hinduism and and get SB to follow. Pacal will be annoyed, you and SB can get together and decide to run a crusade. The dicey part here is balancing the friendship between SB and Pacal (mutual military struggle) against their growing animosity (different religions). If you're lucky, some random events might help.
HRE -> England -> Maya
with Sitting Bull not even on your continent.
I say you use Isabella for a succession of crusades. First, ensure that the HRE is neither Holy, nor Roman, nor an Empire by wiping it out. Then, get Pacal and Sitting Bull on the same page, religion-wise. Make sure that Lizzie is *not* on that same page. Build the AP. Declare war on heathen Elizabeth and build a new Jerusalem on England's green and pleasant land. Lizzie's now getting it from both ends, er, border-wise. She may fight you on the beaches, etc, but she'll fall.
Now you've got you, Pacal and Sitting Bull. If you're daring, you can try the same thing all over again with Pacal. Get him to convert to something else. You and Sitting Bull declare. Lather, rinse, repeat. To get this done, I'd recommend not overly spreading your religion from Continental War I. Perhaps let Pacal maintain his Buddhism, while converting (barely) Sitting Bull. Once you're ready for Continental War II, convert to Hinduism and and get SB to follow. Pacal will be annoyed, you and SB can get together and decide to run a crusade. The dicey part here is balancing the friendship between SB and Pacal (mutual military struggle) against their growing animosity (different religions). If you're lucky, some random events might help.