Well I suppose if there was ever a Civ game that could have a Pirate Republic, Civ VII makes the most sense where it can just exist within the Exploration Age.
Maybe not the most historically impactful Civ since the Flying Gang of Nassau only lasted a few years but it's not like Gran Colombia lasted long either. At least there's plenty of flavor there. Could be fun
Technically, Gran Colombia still exists. The real and legal name of "Gran Colombia" was "Republic of Colombia", which still is the official legal name of Colombia. As a nation, Colombia has existed in some form or another from 1810 to the present (even from 1538 if you count its period as the Spanish colonial kingdom of New Granada).
"Gran Colombia" was just a historiographical name to refer to a period in Colombian history when Colombia was huge, but the nation did not stop existing after that period. Similar to how the "Weimer Republic" refers to a specific period of German history, or the "Byzantine Empire" being used to refer to the late Eastern Roman Empire.
No one ever identified as a "Gran Colombian", they (including Simón Bolívar himself) refered to themselves just as Colombian. There are even laws from back during the "Gran Colombia" period that are still in force in contemporary Colombia.
Also, Colombia (especifically during the period between 1810 and 1833, including the "Gran Colombia" period) was very influential overall, they conquered Ecuador, Perú, Panama, Bolivia and even briefly some parts of Florida and Santo Domingo wanted to join Colombia at some point. Under Simón Bolívar, Colombia (together with Argentina) pretty much put an end to the Spanish Empire and shaped the politics and culture of South America from 1810 to the present. Colombia, together with Argentina, the USA and Chile were amongst the first long lasting attempts at creating "modern" liberal "democratic" presidential republics in the world, while most of Europe remained under absolute monarchies for almost a century more until WWI.
I'm sure Colombia, Argentina, Haiti, Brazil, Chile, even Canada or Cuba, are much, much more influential than a short lived Pirate Republic ever was.
Not to mention the indigenous peoples of the Caribbean and South America (Arawak, Taíno, Caribs, Wayuu, Muisca, Tupi, Tairona, Guna, Emberá, Mapuche etc.) who deserve to be included before a "Pirate Republic" is even considered.