I'd really like if civs got as original look as possible (when compared with Civ series) such as
Greeks finally getting science focus

four editions of civs having bonuses and civ with probably the largest (or among largest civs) impact on the global history of science never having sci bonus
Germany finally getting science focus, seriously, basing an entire German civilization on Prussian militarism is really shallow and kind of unpleasant to them
France getting any focus which isn't culture

such as military or you geuss it: science
England not with focus on water or bowmen but industrial revolution
Spain with no religion or useless colonial bonuses but with, well, anything else
Italians
actually being in the game because they are one of the most important civs ever and different eras is perfect way to introduce them against 'but Roman Empire is totally adequate representation of renaissance Italy' crowd
Persia goddamnit not being Achaemenids and not having Immortal unique unit
Persia being Sassanids
Persia being Islamic
Persia being Islamic and having bonus to science (I'll preorder if they to that - I hate preorders)
Russians with focus unrelated to that idiotic "quantity but no quality army" meme, winter (I hate that meme ever more), colonization of barren cold wasteland as if they were alien species... Perfect would be something about economy or - science. Hey why are you looking at me this way, in civ almost nobody ever got science focus, here one of 7 types of civs is just that.
Indian incarnation not having anything to do with elephants, religion, population and rivers. Preferably powerful military, or economy, or - science (seriously it is my favourite yield and topic! let's just give it to all my favourite civs)
China with powerful economy focus, or expansion
Korea with anything EXCEPT science. It was very cool and advanced civ but I don't know where did they get the idea it was scientific innovator bigger than China lol. It was mostly getting its tech from China, perfecting it and relaying it to primitive, pathetic, backwards, boring Japan at the end of the world where nobody cared what is it doing.
Japan not having militarist focus but something representing the fact it was incredibly isolationist and relatively incredibly peaceful for most of its history, preferably cultural bonus (find me another such populous and advanced civ which casually had periods of centuries without any military conflict)
Central Asian civ toppling the myth of uncivilized nomadic savages, such as Sogdia or Timurids.
Portugal with powerful military (you need to be insane to go with 2m tiny country against the entire Indian Ocean and win)
America having, for once, not stupid weird bonuses such as "line of sight" horror or "naitonal parks and movie studios" but mighty economy and scie...
Zulu being nonexistant, I hate this civ
Absolutely not a single reference to Gandhi in any way, shape or form which is comical, just actually respectable depiction which doesn't treat this man and his philosophy as a joke
Celts with focus not on military but their refined art, culture, metallurgy, urban centres
etc