Just wanted to add this so people would know....when first running the program, you have to select the main Civ 5 directory, NOT the assets folder. This ended up causing a problem with both nexus and lemmy's granny reskinner. If you have already made this mistake, follow these steps:
1. Press start the start button and type in regedit.
2. Under HKEY_CURRENT_USER\SOFTWARE\FIRAXIS\TOOLS you will see a file called ToolAssetPath. Open it and you will be able to change the directory.
3. Change it to the main folder of your civ install. Like C:\Program Files\Sid Meier's Civilization V\
Wanted to give everyone a heads up.