Looks mostly fine, 1TB drives are a bad $/GB. I wouldn't get any computers with internal optical drives, just get a USB blu-ray drive for the same price and you can share it between any of your computers.
Also I hate legacy ports on motherboards, if it were me I'd just figure out a serial -> usb thing, which you'll be able to keep if you still need it when you can't get mobos with serial ports anymore.
Too much RAM, terrible choice of CPU, power supply is way too big (but don't take my word on it), you definitely want a better graphics card if you're using two 1920x1080 monitors, and I don't know about the rest.
I dunno how anybody gets by with less than 16GB of RAM. I'm sitting at 12GB used as I type this, and I don't have anything particularly demanding open. (3.7GB for kernel, 1.6GB for Photoshop, 1GB for Firefox, 1GB for Virtualbox, everything else below 200MB). If I want to open anything really big I'd have to close a bunch of stuff.
CPU isn't particularly terrible, especially for CAD stuff which I assume is heavily multithreaded, and CPU hardly matters for gaming as long as you've got at least four cores.
PSU is probably bigger than needed, I generally look at 650W models as baseline for rigs in that range. AMD processor does take more power though.
Video card isn't unreasonable at that price, I assume games are only going to be on a single monitor, for non-games, video cards hardly matter. (My laptop video card can simultaneously drive a 2880x1800 monitor, two 2560x1400 monitors and a 1920x1200 monitor.)