"Colony Initiative" does not unlock new policies to continue down the Prosperity tree. So picking it offsets the acquisition of every policy for the rest of the game. Settlers are easy to build anyways, especially with (very common) 80-hammer expeditions. Delaying Settler Clans, Mind over Matter, Eudaimonia, and Might/Knowledge/Industry (2nd tree) is a mistake.
Discuss.
Discuss.