Why not? If God is simply the entity that is responsible for the creation of the universe, then it is very possible that God doesn't know about us - or doesn't care about us the same way we don't care about the ant colony that's in your backyard.
If you are refusing to accept this as a possibility, then you have to accept that your definition of God is specialized enough for it to probably be influenced heavily by a specific religion. I am merely talking about the generic God - since we do not know which religion is right about God, if any, and since we don't know anything about God at all - including whether he/she/it actually exists or not - since I'm approaching the question from this angle, I have to be all inclusive and refuse to presume to know anything about God at all - except for the basics, such as "Probably created the universe", and so on.
As such, God could have easily created the universe and left to work on other ones - not caring about this one at all. Or it could have been an accident, created in his lab - a speck of mold under his desk that he isn't aware of either. Or many other scenarios in which he doesn't know or doesn't care about us or our existence at all.