I tried to enjoy multiplayer, and I liked it much, BUT I decided not to play because:
-there were WAAAY to many technical problems:
-Out of Synchron
-5minute wait times, when someone is joining,
-freezing games, when I saved a MP game, I couldnt reload it, cause the turn timer freezed,
-game unplayable at late game, because people keep on joining
-you cannot close player slots
-you have to play 10hours, and you still havent finished a game
-absolute lack of modern era play
-diplomacy is way too easy and unrealistic vs. people, but it's not a negative thing...
-very bad players who are incredibly noob, or cannot speak English
-NO POSSIBILITY to pause the game for a nice 10-20minutes, then rejoin
you have to spend the whole day in front of the PC,
-ladder games suck, cause I am not gonna play a game through in one run
-want to play now and then 1-2hours, save the game, and host it next time, but it's not possible.
-and I forgot: join BUGS, BUGS, BUGS.
I gave it up after 3days of trying. I even wrote a quite long list of how to improve the multiplayer part for casual players, which everyone liked.
http://forums.civfanatics.com/showthread.php?t=140503
The multiplayer interface we have now is really annoying and bad, pity that CIV4 is really awesome in MP, but only if you are an enthusaist, who is willing to play ladder games, and play 5-10-15hours in a row.