I'd be fine with playing the new game only to domination. I've been the biggest advocate of conquest, but getting from the domination point to conquest in this game took us almost two months, so perhaps we can take it easier next time. So, LK, if you're interested, you needn't be deterred by the thought of a conquest endgame, as Greebley says.
As I've said, I'm far more pessimistic than Greebley about allowing the AI to build settlers in this already difficult variant, so my vote would be Israel/no built AI settlers/deity. Keeping Wonder cities is tempting, and I could be convinced if the rest of the team likes the idea, but for the moment I'd say that it dilutes the basic concept too much.