I hope that the dynamic music system has appropriate breadth and excellent songs (some of Civ V's best included Brazil's War theme and England's Peace theme, but there were several other good ones, even though you also had misfires like Morocco's music and India's war theme).
I hope that the new civs will be appropriately varied.
I hope that agendas will not be so overriding that they conflict with logic and reason.
I hope that unique units will prove longer-lasting and more useful than in Civ V.
I hope carpets of doom will be easier to maneuver and control than they were in V.
I hope system requirements will not be huge.
I hope that at least some leader screens will not have sunset lighting in the background, but brighter daytime skies.
I hope that the UI will not have that stupid "pit" sound when I click on buttons (Civ V's buttons always made the "pit" sound).
I hope that when you make buildings in-game, you will get unique sounds fitting that building ala Civ IV, and not the generic building construction noise of Civ V.
I hope that units will speak the civ's native language as in Civ IV.
I hope that the tech tree won't be unduly short.