Sinapus
Defenestrated
I thinks I got the fix. Modify your .ini file. Civ uses virtual memory in a way that windows doesn't like, hence the crashes. Putting the control back into window's hand seems to fix the inability to run the game, although I've had a few anomalies, namely some barbarian bears appear, in a no barbarian game, when tech is in the modern era.
The only anomalies I've noticed so far is that some of the unit animations don't update after they've taken damage. Minor annoyance at worst. I'll have to see if I can complete a game with these settings on the 160x100 map I made.