If Civ V is specifically designed for 64-bit (in other words, requiring more than 2GB of RAM) it will be suicide for Firaxis. That will cut out a huge percentage of their customers. On the other hand, if the game is 64-bit capable but does not require all that much RAM there will be little benefit to it.
This is the dilemma of 64-bit. To get the greatest benefit out of it you need to find a way to use all that RAM. You also don't want to leave money on the table.