Ask a "Mad Scientist"

Given that funding was not an issue, what would you most be interested in researching and who would you most like to be working with?

I am essentially working on what I find interesting right now, I do have a side interest in the biology of aging (not neuroscience related) that I did some work on a few years ago. There is not one particular person that I would like to work with. It is not like there is some genius out there in the field that is inaccessible. I pretty much see everyone in the field at some time or other at meetings and can always get in touch with them if I want. I suppose I could put together an institute that I would find appealing. Having a group of people using different techniques on the question of the neural basis of behavior in the same building would be nice,
 
OK, I read the blog post, but I'm afraid I don't really understand the procedure and its implications.

What does the drug do?

How can you tell that the memories of the two 'boxes' are mixed up in the mouse brains?

How do you do the implantation? Is that the drug's job? If so, how does the drug only interact with the necessary neurons?
 
Does neuroscience have anything to say on the idea that parents who have children when they are older, say 40s to 50s, many have greater possibilities of neurological problems? Or would that fall under other specialties of medicine and biology?
 
Does neuroscience have anything to say on the idea that parents who have children when they are older, say 40s to 50s, many have greater possibilities of neurological problems? Or would that fall under other specialties of medicine and biology?

Do you mean the children? There is greater risk for both genetic and gestational events affecting the child with the age of the mother. There is now evidence for an age of the father genetic risk to the child.
 
Yes, I was referring to if there were known neurological effects with a greater likelihood in the children of older parents (at the time of birth). I guess I can't think of quite how to ask that question more clearly.

As an example, at the time of my birth my mother was 39, my father 44. And both were smokers, to boot :p

Another question, it's well accepted that lead exposure in children has harmful neurological effects. As you recall we used to have leaded gasoline in the US. Have their been studies that show that just living in an area with a lot of roads is a risk factor over children raised in a more isolated area with a lot less gas being burned?
 
Yes, I was referring to if there were known neurological effects with a greater likelihood in the children of older parents (at the time of birth). I guess I can't think of quite how to ask that question more clearly.

As an example, at the time of my birth my mother was 39, my father 44. And both were smokers, to boot :p

Another question, it's well accepted that lead exposure in children has harmful neurological effects. As you recall we used to have leaded gasoline in the US. Have their been studies that show that just living in an area with a lot of roads is a risk factor over children raised in a more isolated area with a lot less gas being burned?

Well the effects I am talking about are severe things seen in children Downs which most people know is a risk with mothers age but also things like Autism and more rare disorders I think have elevated risk with parental age.

If you are trying to explain any neurological symptoms you have as an adult there are just not studies I am aware of that follow this sort of thing into adulthood.

Also not aware of lead pollution studies.
 
Speaking of lead: While browsing wikipedia recently, I found this (http://en.wikipedia.org/wiki/Crime_in_the_United_States#cite_note-8):

As shown in the charts above, reported violent crime nationwide [US] nearly quadrupled between 1960 and its peak in 1991. Property crime more than doubled over the same period. Since 1993, crime has declined steeply. Several theories have been proposed to explain the cause.
...
Another hypothesis suggests reduced lead exposure as the cause; Scholar Mark A.R. Kleiman writes: "Given the decrease in lead exposure among children since the 1980s and the estimated effects of lead on crime, reduced lead exposure could easily explain a very large proportion—certainly more than half—of the crime decrease of the 1994-2004 period. A careful statistical study relating local changes in lead exposure to local crime rates estimates the fraction of the crime decline due to lead reduction as greater than 90 percent.

Have you ever heard of that?
Do you think such a claim is somewhat credible?
 
Speaking of lead: While browsing wikipedia recently, I found this (http://en.wikipedia.org/wiki/Crime_in_the_United_States#cite_note-8):



Have you ever heard of that?
Do you think such a claim is somewhat credible?

I've not heard of this. It could be a credible correlation if you could show differences across areas with different lead levels but I wouldn’t take it too seriously as it is difficult to control for all the potential covariables. Also, I think the mechanism of lead effects is on neural development so you would expect the effect to show up 10 yrs later say when 8 yr olds exposed to lead grow to 18 yr olds or more and enter the violent crime years.
 
When I think to myself, my inner monologue feels as if it is happening in my head. Is that real, or am I just projecting the physical sensation to where I know my brain is? Put another way, if I didn't know what a brain does, might I feel my thoughts originate somewhere else or even nowhere at all?
 
Our brain has a lot of visual cortex, and quite a bit of auditory cortex. Your sense-of-self tends to float somewhere behind your eyes. This isn't so much to do with where your brain is, as where your eyes are.

A congenitally deaf and blind person might feel differently, because they've got fewer of their senses sequestered in their head. That said, the face takes up a lot of room on the somatosensory cortex, so they still might feel like 'they' exist in their head. But it's a good question
 
Why don't you look anything like the mad scientists in the movies and frequently in real life like Martyn Poliakoff?

poliakoff.jpg
 
Do you have any sort of moral or ethical problem with giving mice electric shocks to induce fear in them?
 
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