Mobilize said:
The Seneca were part of the Iroquois Confederation. However the Cherokee had a town called Seneca, I don't know if it has any relation, but geographically it wasn't close at all to the Seneca who were located in modern day Canada and Seneca was in South Carolina.
The Seneca called themselves Onotowaka, so probably it was (like so many other things) a mix-up on the part of European geographers/historians. "Iroqouis" is another mix-up, it means "real snakes" (lol) and was a sort of racial epithet their enemies called them (real name was Haudenosaunee, People of the Longhouse).
The Seneca were in the US btw, as with the rest of the Confederacy, along the south shores of Lake Erie and Lake Ontario, extending up to the Thousand Islands area of the St. Lawrence, but primarily centered in what is now northern NY state. Only a small fraction of their traditional territory lay in Canada although they did establish some colonies beyond their normal range after the fur trade got established. To the north of the Iroquois were the Huron, who at one point dominated what is now Quebec and parts of eastern Ontario.
I think the mix-up of names might have something to do with the Tuscarora (real name Skaruren - "hemp folk"!). They were pushed out of the Carolinas by settlers around 1710, fled over the Appalachians, and wound up in Iroquois territory in 1722, joining the Confederacy and becoming the Sixth Nation. It's quite likely they were in contact with the Cherokee, whose traditional home along the borders between Georgia and Carolinas I think? They were sure to have been in contact as their traditional lands are fairly nearby to each other.
I'm rather sketchy on the history of groups in the southern and western US (like the Cherokee, or the Plains groups) so I'm not really sure if I'm placing the Cherokee right, or where exactly in the Carolinas the Tuscarora homeland would have been before the 1700s. What I've heard (not sure how reliably) is that the Tuscarora were centered in the Appalachians right around where the North Carolina/Virginia border hits the foothills, and extending a bit onto the coastal lowlands, and the Cherokee ranged to the south and west of the southern tip of the Appalachians, in the northern part of Georgia and the west part of South Carolina (before the Trail of Tears, that is). If that's right they were practically next door neighbours at one point, so it's possible that's where the word came from perhaps?
I'm not too familiar with the Cherokee really, how exactly were they organized? Was it a confederation of tribes, or just one really large tribe?