What resolution are you running at? I had problems first time I tried to run it, couldn't even kill it in task manager finally had to reset the computer, now it runs ok. I'm pretty sure it has to with my 4k resolution, other resolutions my be a problem too (Civ5 does a similar thing not working the first time I try to run it in 4k mode). You might check the graphics configuration file, see if it has the correct resolution in it and you could try setting FullScreen to 0 (windowed mode). Also are your graphics drivers up to date?