Interbreeding with them?
I maintain that humans are fundamentally animals with fundamentally animal physical/social/mental/emotional requirements, and that "upgrading" to a machine defeats the purpose of living and removes much of your humanity. This "upgrade" seems to entail committing suicide and having a very close digital replica of your mind constructed. It may "think" like you, act like you (minus those apparently "inferior" animal urges and needs), it may even have your memories, but it's no more "you" than a twin, and a society that embraces singularity seems to be killing itself off so that computer programs can simulate happiness. I find that pointless and horrifying.
It's this whole "change in ways that aren't necessarily better or die" attitude that irks me about technophiles. Ultimately, the purpose of all human actions seems to be survival, happiness, or the avoidance of unhappiness. The human species can survive just fine without becoming machines or computer programs, and it can be happy as well. There is no "need" for the singularity. But too often, technology and other developments don't make people happier, so much as they make them better at killing and oppressing each other. The creation of the state may not have been a good move in ensuring that people led meaningful, enjoyable lives (what with their impersonal nature, oppressive power structures, and violence), but stateless societies rarely last long against a state's application of military, economic, and demographic pressure. Even without smallpox and other diseases annihilating them, the various stateless peoples of North America and Siberia would have had a very hard time resisting the sheer numbers of organized, wealthy, heavily armed professional European troops and settlers, regardless of whether or not those stateless societies were more pleasant to live in generally. Which is awful, and not something to be lauded.
This doesn't mean that humanity is doomed, necessarily. Hopefully, posthumans will be merely computer programs with little in the way of physical needs. They shouldn't compete much with humans for resources or land, and maybe they could exist on planets inhospitable and useless to humans such as Venus or Mercury. After all, they would exist mainly digitally; the physical world would matter little to posthumans, so long as whatever physical devices that power and house them remain intact and functioning. Me, I love the physical world and would never willingly part with it, but some posthuman program couldn't care less about whether it has a lot of land and a yacht and my country's natural resources so long as it can continue to operate and "enjoy" its simulated existence.
Just do humans a favor and leave us be. Quit life if you want to, but there's no need to eliminate or oppress humans if "you" are just a program.