I've noticed many city states are getting picked off before I have a chance to get to them. In my deity Pericles game I'm running, I had to protect Zanzibar from an early Egyptian rush, but of course other CS's on the other sides of the map were immediately wiped. Now in the late game, there's only 3 left. And with Amani doubling envoys to them (who the AI love to pick, usually first in my experience) it's only realistic getting 2 of them.
How viable is the globalization method because of all this? E-Commerce is still fantastic, but I'm not sure how to still pull this off, considering how quickly they're being eliminated.