Hi! All mechanics of this mod (mainly dissent) adapt perfectly to the diverse settings of difficult, speed, and map size. As far as I know, the dissent mechanic will penalize harder to you compared to the AI civs when you get into the hardest difficulty levels.
So don't think there's a specific difficulty level suited to this mod. It's all up to you and your preferences. I would recomend you to play a first game on an easy difficulty level just to test the dissent mechanic.
Personally I enjoy to play on slow speeds (saga or marathon) and World map type (large or standard size).
(Not english native speaker, hope I express enough well)