Actually running off my backup hard drive worked especially well. Although it takes a while to build shaders when loading the game, but I suspect that has to do with my video card, not my hard drive. This game doesn't seem to run any slower than Inquisition which I have on my 10,000 RPM hard drive where as Andromeda is on my 7200 RPM hard drive.
Of course I've stopped playing as I'm bored of the game already.

I mentioned some of the problems in the off topic thread about what game you are currently playing. I may eventually finish. But the game is just too large, and the story isn't engrossing enough for me to finish. Getting Eos to 100% viability bored me to tears. Havarl wasn't bad, that planet is about the right size, not too big. Eos is just a pain, and this planet alone caused me to stop playing.
The game itself runs pretty good. I don't mind sacrificing some FPS to have graphical settings up higher, I did it with Inquisition too. In fact, my current video card I bought just so I could play inquisition at high settings.
Processor: AMD Phenom II X 4 945 processor 3.00 GHz
8.00 GB of RAM
64 bit OS (Windows 10)
Geforce GTX 970 (4 GB of RAM on the video card)
This computer I built in 2009. The only changes I've made have been the video card mentioned above, and adding a 10,000 RPM hard drive as my main hard drive (my previous main is now my backup and where I keep most of my media like videos and songs). I'm still not ready to go solid state hard drive (I hear they have a limited amount of rewrites). Overall I'm happy with running the game on my backup hard drive, and any future games I'll probably put there. As I don't like having to delete games to add new games. I already deleted World of Warcraft, but I don't intend on playing that game again, that game takes up a huge amount of HD space.