There's a woman on the radio who just published a book about the explosion of allergies in children. She says three things correlate with kids that have fewer allergies: Older siblings, going to daycare, and having a family dog. I'd heard before that having a dog as a kid can help your immune system; I hadn't heard about older siblings and going to daycare, but I suppose that makes sense too, for similar reasons.

 
There's a woman on the radio who just published a book about the explosion of allergies in children. She says three things correlate with kids that have fewer allergies: Older siblings, going to daycare, and having a family dog. I'd heard before that having a dog as a kid can help your immune system; I hadn't heard about older siblings and going to daycare, but I suppose that makes sense too, for similar reasons.

I am generally into having a certain amount of allergen exposure to keep your immune system balanced, but that does not have to include letting a dog lick your face. If you are considering that you need to know about cutaneous/ocular/cerebral larva migrans.
 
Biggest ever study of primate genomes has surprises for humanity (Summary of 10 papers, see article for all links)

The largest ever study of primates has unveiled surprises about humanity and our closest relatives, providing insight into which genes do, and don’t, separate us from other primates. The huge international study has also yielded new data for a wide range of disciplines, including human health, conservation biology and behavioural science.

More than 500 species of primate exist today, including humans, monkeys, apes, lemurs, tarsiers and lorises. Many are threatened by climate change, habitat loss and illegal hunting. Researchers sequenced genomes from nearly half of all primate species, investigating more than 800 genomes from 233 species around the world, representing all 16 families of primate.

The primate resource promises to help researchers improve their understanding of human biology and disease. In one study by Marquès Bonet and others, the genomes of the 233 primate species were used to classify 4.3 million common gene variants present in the human genome. By assessing how common those variants were across species, the researchers were able to infer that around 98.7% of the variants they checked are probably benign in humans. This information could be used to help identify disease-causing mutations in people who have had their whole genome or their exome — the protein-coding portion of the genome — sequenced.

In another study, Wu and his colleagues compared the genomes of 50 species to map how the primate family tree evolved. They identified thousands of genetic sequences that became dominant over evolutionary time in various branches of the tree. For instance, genes involved in brain development arose in the common ancestors of humans, apes and new world monkeys, and set the stage for the rapid evolution of large brains in humans. “Brain expansion began a long time ago,” says Wu.

Meanwhile, a large cache of gene variants thought to be unique to humans, because they are found in Homo sapiens but not in the archaic human relatives called Neanderthals and Denisovans, has turned out to be widespread across primates. Almost two-thirds of the variants thought to be solely human were present in at least one other primate species, and more than half were found in two or more.

By comparing the genomes of the social snub-nosed monkeys with genomes from less-social related monkeys, known as odd-nosed monkeys, and with those of more distant primate relatives, Qi and his colleagues identified genes that seem to be connected with the formation of large multilevel societies. The group found that changes in climate more than six million years ago drove the monkeys’ social structure to shift from small groups with one male and a few females to complex societies with multiple males and females.

The analysis of all 233 species’ genomes also has implications for conservation. For example, it shows that genetic diversity within a species does not align with its extinction risk. That’s surprising, says Behie, because lower genetic diversity, which can result from inbreeding when population size diminishes, is widely considered a sign that a species is at risk of extinction. The finding suggests that for some threatened species, populations have declined so fast that there hasn’t been time for inbreeding to occur. This points to factors other than inbreeding — such as habitat destruction — being the greater threat to a species’ resilience.


The hierarchical monkey? The golden snub-nosed monkey (Rhinopithecus roxellana) is one of only a handful of primate species that have complex multilevel social structures.
 
That is a very cute monkey!
 

Distillery develops dairy-to-fuel process​

Ethanol made from milk seen as a way to offset carbon

A distillery known for vodka distilled from milk byproduct has partnered with a U.S. dairy producer who will use the eastern Ontario company's process to produce eight million litres of ethanol fuel that is better for the environment than conventional transportation fuel.

Dairy Distillery in Almonte takes milk permeate — the lactose and minerals remaining after milk undergoes filtration — adds yeast and ferments the permeate into a low-alcohol "wine."

That weak milk permeate wine can then be distilled into a stronger ethanol alcohol the company claims to be the world's lowest carbon-intensity ethanol.

A similar process is used to create Dairy Distillery's "Vodkow" spirit.

"We always knew there was a big application for this sugar," said Dairy Distillery founder and CEO Omid McDonald at the company's headquarters just west of Ottawa.

McDonald didn't realize how big until he was contacted by the Michigan Milk Producers Association, a 107-year-old co-op representing about 1,000 dairy producers in that state, as well as in Ohio, Indiana and Wisconsin.

The organization is a major producer of waste permeate annually and had plans to bottle it up to sell on liquor store shelves, but that plan didn't add up, said president Joe Diglio.

That's when it decided to build a bigger version of the distillery in Constantine, Mich., to convert the milk permeate into an alcohol.

The alcohol is then blended with transportation fuel to make permeate ethanol they believe will offset 14,500 tonnes of carbon each year.

"You start to realize that these byproducts have opportunities," said Diglio, who believes the offset will reduce the carbon footprint of the milk processed at the new plant by five per cent.

The group aims to hit a U.S. dairy industry goal of net zero carbon emissions by 2050.

Be careful of 'green-washing,' expert says​

The plan might look good for dairy experts, but milk ethanol-powered cars could be a little ambitious.

"We do want to be vigilant about green-washing," said Heather McLeod-Kilmurray, who teaches environmental law at the University of Ottawa.

She said the diversion of a food waste stream into a fuel for the mid-term future is probably a good first step.

McLeod-Kilmurray did warn of relying on fuel sources when cleaner power innovations come along.

Ethanol production at the Michigan plant is expected to begin in early 2025.

"You never know when you start out the door where it will take you and you have to be open to new ideas," said McDonald about the distillery's process growing in the U.S.

"The hope is that once we get it going there, it will be adopted here, as well."
https://www.cbc.ca/news/canada/ottawa/almonte-dairy-distillery-ethanol-fuel-michigan-1.6865954
 

Scientists map medieval town that's been buried beneath the sea for 661 years​

Researchers find what they believe is the central church of Rungholt, the 'Atlantis of the North Sea'

Rungholt was once a booming trade town where residents reaped profits from the land's bountiful natural resources — until a changing climate and rising sea levels ripped it all away.

The story may sound eerily familiar, but it happened 661 years ago.

Now — thanks to advancements in technology that allow scientists to identify structures buried deep beneath the Earth's surface — researchers are learning more about this medieval city that's been long buried off the coast of Germany.

"This is really a major problem we are facing today in many places of the world with rising sea levels," says Bente Majchczack, an archeologist from Germany's Kiel University who is helping to map the ancient town.

"We can see how the people lived there, and how they reacted — and how they ultimately failed — in maintaining this landscape," he told As It Happens guest host Helen Mann.

'Atlantis of the North Sea'

Rungholt was a 12th-century Frisian colony that, in the years since its destruction, has gained an almost mythical status. It's widely known as "the Atlantis of the North Sea" — much to Majchczack's chagrin.

But while Atlantis is, as far as anyone knows, fictional, Majchczack says Rungholt was a very real Medieval trading hub that met a grisly fate in 1362 when a powerful storm surge completely submerged it.

Its remnants, he says, are buried beneath the muddy flats near the German island of Hallig Südfall in the Wadden Sea.

That's where he and a team of researchers, funded by the German Research Foundation, are using a combination of geoscientific and archaeological methods to paint a picture of the town.

"We're doing a magnetic survey," he said. "And this enables us to find all these buried structures and to map them out really in a black and white map where we can see what's left of the Middle Ages in this area."

So far, the team has mapped about 10 square kilometres, including 54 terps — or artificial mounds upon which medieval settlements were built — as well as systematic drainage systems, a sea dike with a tidal gate harbour and two small churches.

But they came upon their most significant discovery last month — the foundations of what they believe was a 40-by-15-metre church built upon a previously unknown two kilometre long chain of terps. This was likely the town's central church, and a major community hub.

Kiel University geophysicist Dennis Wilken had the eureka moment.

"He was pushing the cart with the magnetic probes and he had found a new terp and was looking at the measurements … and then he realized what he was seeing on the screen," Majchczack said.

"I wasn't there. But a colleague said, 'And suddenly, he started dancing.' So ... it was really a very, very special moment."

'The Great Drowning of Men'

What's interesting about Rungholt, Majchczack says, is that it was built somewhere not at all suitable for human settlement.

"It was like a natural landscape of peat bogs and fenland. It was very uninhabitable, and they completely colonized it. They completely changed the landscape," he said.

"Once you remove all this peat and get the water out, you have very, very rich soils that are perfect for agriculture … and that must have been quite profitable."

Profitable, but not, it would seem, sustainable.

"This backfired on them because they created huge vulnerabilities," Majchczack said. "With rising sea levels and increasing storminess, one day these dikes they built were not sufficient enough, and these settlements just drowned. Everything was destroyed."

The storm that did Rungholt was a whopper. It swept across Ireland, Britain, the Low Countries, and northern Germany, causing at least 25,000 deaths, according to the Guardian, in an event now known as the Grote Mandrenke — or the Great Drowning of Men.

Both the storm and the destruction of Rungholt have long captured peoples' imaginations. For example, Majchczack says stories often paint it as a much bigger city than it actually was.

And one legend that's been passed down over the ages is that God brought on the storm to punish the residents of Rungholt whose wealth and abundance caused them to live lives of drunkenness, debauchery and sin.

'A cautionary tale'

Historians have hailed the Rungholt Project for using a multi-disciplinary approach and new technology to unlock the secrets of the past.

Western University historian Mitchell Hammond, who was not involved in the research, says that when Rungholt was being built, the climate was "exceptionally warm" and "expanding populations were resourceful in new exploitation of land and sea."

"By 1360, the region was well into the so-called 'Little Ice Age,' which was not only colder but more to vulnerable disasters like the cyclone flood that apparently wiped out Frisian coastal villages in early 1362. Land-use decisions that seemed sound to coastal dwellers in the 1200s set up later problems," Hammond, who studies ancient German cities, said in an email.

"It's a cautionary tale for coastlines today in an era of even more profound climate upheaval. "

David Perry — a medieval historian based in Minnesota, and co-author of The Bright Ages: A New History of Medieval Europe — agrees.

"This work continues to help redefine our understanding of medieval Europe, including this city on a northerly coast, as a connected, permeable, complex world with connections that stretch across continents and seas," he said.

"Rungholt and its fate is a human story, and I hope we can always see medieval people as different than us in many ways, but still humans, our fellows, with all the potential for joy and tragedy that the human condition brings."
https://www.cbc.ca/radio/asithappens/rungholt-church-discovery-1.6870278
 
The Moral Hazards Of Being Beautiful
Research shows that attractive people tend to receive unearned esteem from others and cultivate self-serving beliefs.
BY EMILY BOBROW

Beauty has its privileges. Studies reliably show that the most physically attractive among us tend to get more attention from parents, better grades in school, more money at work and more satisfaction from life. A study published in January in the Journal of Economics and Business found that good-looking banking CEOs take in over $1 million more in total compensation, on average, than their lesser-looking peers. “Good looks pay off,” the authors write. New research from Shanghai Advanced Institute of Finance similarly finds that comely managers of mutual funds lure more investments and enjoy more promotions than their homelier counterparts, even though their funds don’t perform as well. The researchers suggest this performance gap may be because handsome managers approach risk with hubristic levels of confidence.

While we like to say that beauty is in the eye of the beholder, studies consistently show that most people prefer smooth skin, thick shiny hair and symmetrical bodies, as well as height for men and curves for women. We are suckers, basically, for signs of youth, good health and reproductive fitness. “Look, if there were no standards, then beauty would have no impact,” says economist Daniel Hamermesh, author of the 2011 book “Beauty Pays.” Scientists attribute the human tendency to give attractive people better treatment to something called the halo effect. Basically, we tend to assume that good looks are a sign of intelligence, trustworthiness and good character and that ugliness is similarly more than skin deep. “Personal beauty is a greater recommendation than any letter of reference,” Aristotle observed. This may help explain why attractive people are less likely to be arrested or convicted, even after controlling for criminal involvement, according to a 2019 study of nationally representative data published in the journal Psychiatry, Psychology and Law.

Given all the benefits afforded to the beautiful, it’s surprising that there has been so little research on how lookers actually behave. Are good-looking people actually more likely to be good, or do they exploit their advantages for personal gain?
Xijing Wang, a social psychologist at City University of Hong Kong, addressed these questions in a set of five experiments involving more than 1,300 participants in the U.S. and China, published in the journal Evolution and Human Behavior in November 2022. After giving people money and raffle tickets and asking them to share, Wang and colleagues found that those who rated their own looks highly were more likely to keep the items for themselves. Participants who were primed to feel more attractive were also more likely to agree with the statements “I demand the best because I’m worth it” and “I feel entitled to more of everything.” “Due to their great bargaining power, attractive individuals may have learned that they deserve better,” Wang writes. Yet this sense of entitlement was apparent only when participants knew their actions and responses were anonymous. When their choices could be seen and noted by others, even the comeliest curbed their selfishness. “In other words, due to image or reputation concerns, attractive people may not want to demonstrate self-interested behavior in public,” Wang explains.

Her findings reinforce other studies that show that physically attractive people often cultivate self-serving beliefs. A 2014 paper in the journal Organizational Behavior and Human Decision Processes, for example, found that those who saw themselves as good-looking sensed they had more power and higher status than their plainer peers. They were also more likely to attribute growing economic inequality in the U.S. to the hard work and talent of those at the top. Participants who were prompted to recall a time when they felt alluring were more inclined to agree with the statements ‘‘Having some groups on top really benefits everybody’’ and ‘‘Some groups of people are simply inferior to other groups.” They were also less likely to donate a $50 gift card to charity than those who were asked to recall a time when they felt ugly.

These findings are in keeping with an extensive literature on how people rationalize luck. Essentially, lucky people tend to believe that life is fair and fate rewards merit, whereas unlucky people are often more alert to systemic bugs and more supportive of efforts to correct for them. A 2016 study in the Journal of Public Economics, for example, found that people who were randomly assigned hard counting tasks in a lab were more inclined to blame their poor performance on circumstantial factors, such as the clarity of the instructions, and more likely to share tokens in a subsequent game. Those who enjoyed an easier counting task not only ascribed their success to personal effort but also were considerably stingier with the tokens. “If people win the genetic lottery, they get many societal advantages, and this in turn affects their views of the world,” says Andrea Fazio, an economist at Tor Vergata University of Rome. Fazio analyzed a nationally representative survey of Germans who rated how much they agreed with statements about money and fairness, such as “Income and wealth should be redistributed towards ordinary people.” The results, which he reported last year in the journal Economics & Human Biology, showed that the respondents who were seen as physically attractive by interviewers were also more likely to say that efforts to redistribute wealth were wrongheaded because everyone gets what they deserve.



’If people win the genetic lottery, they get many societal advantages, and this in turn affects their views of the world.’
ANDREA FAZIO Economist

“Is this purely selfish behavior? I don’t know,” Fazio observes. He notes that while attractive people may be moved to rationalize or dismiss their social and labor-market advantages, they might think or behave differently if they understood the extent to which they benefited from a beauty premium. “Maybe they would be more generous if they knew how much luck was involved.” Although studies are scarce, it would be wrong to say that beautiful people reliably defy presumptions of goodness. In three large surveys of Americans published in 2020 in Nonprofit and Voluntary Sector Quarterly, researchers found that attractiveness correlated with slightly more reports of volunteering or donating money to friends. The authors allow, however, that this could be because good-looking people tend to have wider social networks, so they are probably asked for help or money more often. “It is also possible that more attractive people may crave social desirability and hence be more likely to over-report their giving behaviors,” they add.

Yet those of us who never got that genetic golden ticket should take heart: The halo effect appears to go both ways. A number of studies show that goodness often enhances our looks. A paper in PLOS One in February, for example, reports that people found faces in photos more attractive when they learned the subjects were honest, kind and not aggressive. The results suggest that “facial attractiveness is malleable,” the authors write. Or as Sappho observed: “What is beautiful is good and what is good will soon be beautiful.”

LIBBY EDWARDS
 
One way booze is good for you

Alcohol’s beneficial effect on cardiovascular disease is partially mediated through modulation of stress-associated brain activity

Background
Chronic stress associates with major adverse cardiovascular events (MACE) via neural mechanisms. We hypothesized that moderate alcohol intake decreases stress-related neurobiological (amygdalar metabolic activity, AmygA) and that this neural effect mediates the beneficial impact of alcohol on MACE

Methods
Data were obtained from a Partners Biobank healthcare survey of 50,559 participants with median age 60 years [interquartile range 45, 70]. Of these, a subset of 752 had undergone 18F-fluorodeoxyglucose positron emission tomography imaging. Alcohol intake was classified as low (<1 drink/week), moderate (1-14 drinks/week) or high (>14 drinks/week). AmygA was measured as the ratio of amygdalar to pre-frontal cortical activity. MACE was determined using International Classification of Disease (ICD) codes

Results
Of the 50,559 participants, 6,648 (13.1%) experienced a MACE. Moderate alcohol intake associated with reduced MACE risk (odds ratio [95% confidence interval (CI)]: 0.870 [0.816, 0.928], p<0.0001 and with decreased AmygA (standardized β [95% CI]: -0.088 [-0.031, -0.003], p=0.018) in adjusted analyses (see figure). Mediation analysis demonstrated that reduced AmgyA in part mediated alcohol’s beneficial effect on MACE, (log odds [95% CI]: -0.035 [-0.088, -0.001], p<0.05)

Conclusion
Moderate alcohol intake attenuates MACE risk in part by lowering stress-related neurobiological activity. New therapies with similar stress reduction but fewer toxicities are needed

 
How psychedelic drugs achieve their potent health benefits
Mouse studies suggest that drugs from LSD to ecstasy renew the brain’s flexibility — but some scientists are sceptical.

Psychedelic drugs are promising treatments for many mental-health conditions, but researchers don’t fully understand why they have such powerful therapeutic effects. Now, a study in mice suggests that psychedelics all work in the same way: they reset the brain to a youthful state in which it can easily absorb new information and form crucial connections between neurons.

The findings raise the prospect that psychedelic drugs could allow long-term changes in many types of behavioural, learning and sensory system that are disrupted in mental-health conditions. But scientists caution that more research needs to be done to establish how the drugs remodel brain connections.

Psychedelics such as MDMA (also known as ecstasy), ketamine and psilocybin — the active ingredient in magic mushrooms — are known for producing mind-altering effects, including hallucinations in some cases. But each compound affects a different biochemical pathway in the brain during the short-term ‘trip’, leaving scientists to wonder why so many of these drugs share the ability to relieve depression, addiction and other difficult-to-treat conditions in the long term.

Gül Dölen, a neuroscientist at Johns Hopkins University in Baltimore, Maryland, and her colleagues sought answers by studying how psychedelics affect social behaviour in mice. Mice can learn to associate socializing with positive feelings, but only during an adolescent ‘critical period’, which closes as they become adults.

The scientists trained mice to associate one ‘bedroom’ in their enclosure with mousy friends and another room with solitude. They could then examine how psychedelics affected the rodents’ room choices — a proxy for whether the drug affects the critical period.

Dölen’s team had previously found that giving MDMA to adult mice in the company of other mice reopened the critical period, making the MDMA-treated animals more likely to sleep in the social room than were untreated mice. This was not surprising: MDMA is well known for promoting bonding in some animals and in humans.

For their new paper, the researchers gave adult mice either MDMA or one of four psychedelic drugs not known to promote sociability: ibogaine, LSD, ketamine and psilocybin. Mice that received any of the psychedelic drugs were more likely to choose the social room than untreated mice, suggesting that each of the drugs could reopen the critical period.

But mice did not prefer the social room if given enough ketamine to make them unconscious and therefore unaware of their companions. This suggests that the drugs only open the social critical period if they are taken in a social context. Each drug opened the critical period for a different length of time, ranging from one week for ketamine to more than four weeks for ibogaine.

Next, the team looked at the animals’ brains. They found that in certain brain regions, neurons had become more sensitive to the ‘love hormone’ oxytocin. Dölen suspects that the drugs confer a state called metaplasticity on the neurons, making the cells more responsive to a stimulus such as oxytocin. This state makes them more likely to rewire and form new connections that would indicate the neurons were responding. The neurons also started expressing genes involved in regulating a protein matrix on their surface. Modifying this matrix, Dölen says, could free the neurons’ branches to grow and find new connections.

Dölen argues that psychedelics function as a master key that can unlock many kinds of critical period — not just one for sociability — by bestowing metaplasticity on neurons. The end result depends on the context in which the drugs were taken: the level of social engagement, in this case. The results indicate, she says, “that there’s some mechanistic relationship between critical period opening and that altered state of consciousness that’s shared by all psychedelics”.

Takao Hensch, a neurologist at Harvard University in Cambridge, Massachusetts, says the paper is “pioneering” in finding biological mechanisms for how psychedelic drugs work. “It gives hope that [critical periods] are not irreversible and a very careful cellular understanding of psychedelic drugs might hold the key to reopening brain plasticity,” he says. He adds that social behaviour is very complex and that the drugs’ effects should be studied in other brain regions.

David Olson, a biochemist at the University of California, Davis, is sceptical. The drugs, he says, could be changing physical connections between neurons in certain parts of the brain, rather than inducing metaplasticity that makes the neurons more open to influence by environmental stimuli.

Dölen is now testing whether the psychedelic drugs can reopen other types of critical period, including those for the motor system. Reopening it, she says, could lengthen the amount of time that people who have had strokes can benefit from physical therapy, which currently works only in the first few months after a stroke.

Writeup Paper

The durations of acute subjective effects in humans are proportional to the durations of the critical period open state in mice.



a, Durations of the acute subjective effects of psychedelics in humans. b, Durations of the critical period open state induced by psychedelics in mice.
 
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This I think is real news. It is likely to be years before it hits the clinic, but how frequently does a new etiology of a major condition discovered?

Could endometriosis be caused by bacteria?

Infection by a particular group of bacteria could be linked to endometriosis, a painful condition that affects up to 10% of women and girls of reproductive age.

In a study of 155 women in Japan, members of the bacterial genus Fusobacterium were found in the uteruses of around 64% of those with endometriosis, and 7% of those who do not have the condition. Follow-up experiments in mice infected with Fusobacterium showed that treatment with an antibiotic could reduce the size and frequency of the lesions, which are associated with endometriosis.
 
How psychedelic drugs achieve their potent health benefits
Mouse studies suggest that drugs from LSD to ecstasy renew the brain’s flexibility — but some scientists are sceptical.

Psychedelic drugs are promising treatments for many mental-health conditions, but researchers don’t fully understand why they have such powerful therapeutic effects. Now, a study in mice suggests that psychedelics all work in the same way: they reset the brain to a youthful state in which it can easily absorb new information and form crucial connections between neurons.

The findings raise the prospect that psychedelic drugs could allow long-term changes in many types of behavioural, learning and sensory system that are disrupted in mental-health conditions. But scientists caution that more research needs to be done to establish how the drugs remodel brain connections.

Psychedelics such as MDMA (also known as ecstasy), ketamine and psilocybin — the active ingredient in magic mushrooms — are known for producing mind-altering effects, including hallucinations in some cases. But each compound affects a different biochemical pathway in the brain during the short-term ‘trip’, leaving scientists to wonder why so many of these drugs share the ability to relieve depression, addiction and other difficult-to-treat conditions in the long term.

Gül Dölen, a neuroscientist at Johns Hopkins University in Baltimore, Maryland, and her colleagues sought answers by studying how psychedelics affect social behaviour in mice. Mice can learn to associate socializing with positive feelings, but only during an adolescent ‘critical period’, which closes as they become adults.

The scientists trained mice to associate one ‘bedroom’ in their enclosure with mousy friends and another room with solitude. They could then examine how psychedelics affected the rodents’ room choices — a proxy for whether the drug affects the critical period.

Dölen’s team had previously found that giving MDMA to adult mice in the company of other mice reopened the critical period, making the MDMA-treated animals more likely to sleep in the social room than were untreated mice. This was not surprising: MDMA is well known for promoting bonding in some animals and in humans.

For their new paper, the researchers gave adult mice either MDMA or one of four psychedelic drugs not known to promote sociability: ibogaine, LSD, ketamine and psilocybin. Mice that received any of the psychedelic drugs were more likely to choose the social room than untreated mice, suggesting that each of the drugs could reopen the critical period.

But mice did not prefer the social room if given enough ketamine to make them unconscious and therefore unaware of their companions. This suggests that the drugs only open the social critical period if they are taken in a social context. Each drug opened the critical period for a different length of time, ranging from one week for ketamine to more than four weeks for ibogaine.

Next, the team looked at the animals’ brains. They found that in certain brain regions, neurons had become more sensitive to the ‘love hormone’ oxytocin. Dölen suspects that the drugs confer a state called metaplasticity on the neurons, making the cells more responsive to a stimulus such as oxytocin. This state makes them more likely to rewire and form new connections that would indicate the neurons were responding. The neurons also started expressing genes involved in regulating a protein matrix on their surface. Modifying this matrix, Dölen says, could free the neurons’ branches to grow and find new connections.

Dölen argues that psychedelics function as a master key that can unlock many kinds of critical period — not just one for sociability — by bestowing metaplasticity on neurons. The end result depends on the context in which the drugs were taken: the level of social engagement, in this case. The results indicate, she says, “that there’s some mechanistic relationship between critical period opening and that altered state of consciousness that’s shared by all psychedelics”.

Takao Hensch, a neurologist at Harvard University in Cambridge, Massachusetts, says the paper is “pioneering” in finding biological mechanisms for how psychedelic drugs work. “It gives hope that [critical periods] are not irreversible and a very careful cellular understanding of psychedelic drugs might hold the key to reopening brain plasticity,” he says. He adds that social behaviour is very complex and that the drugs’ effects should be studied in other brain regions.

David Olson, a biochemist at the University of California, Davis, is sceptical. The drugs, he says, could be changing physical connections between neurons in certain parts of the brain, rather than inducing metaplasticity that makes the neurons more open to influence by environmental stimuli.

Dölen is now testing whether the psychedelic drugs can reopen other types of critical period, including those for the motor system. Reopening it, she says, could lengthen the amount of time that people who have had strokes can benefit from physical therapy, which currently works only in the first few months after a stroke.

Writeup Paper

The durations of acute subjective effects in humans are proportional to the durations of the critical period open state in mice.



a, Durations of the acute subjective effects of psychedelics in humans. b, Durations of the critical period open state induced by psychedelics in mice.
Yeah you gotta be careful w mdma w strangers because it increases openness & sensitivity which may be be a good idea w some chick you barely know! People usually think of drug harms as potential risk to brain or body but social/emotional risks are real as well (as of course are benefits)
 
Mum’s microbes might boost brain development of c-section babies
Vaginal seeding is safe and seems to benefit infants delivered by the surgery — but larger trials are needed.

Swabbing caesarean-section babies with their mum’s vaginal fluids to encourage the development of a microbiome seems to be safe — and might improve brain development, finds the biggest-yet study of the controversial practice.

The randomized and blinded trial of 76 infants and mothers found that babies who had been swabbed with vaginal fluids from their mothers achieved a slightly higher number of neurodevelopmental milestones by three and six months than did c-section babies who did not receive the treatment. But it is not clear whether these differences will be meaningful or lasting, say scientists.

“This is not going to make a difference between going to Harvard or not,” says Jose Clemente, a microbiologist at Icahn School of Medicine at Mount Sinai in New York and a co-author of the study, which was conducted at a hospital in China. “It’s up to future studies to determine exactly what the mechanism is and how can we maximize the benefit.”

Microbiome’s birth
Mothers who deliver their babies naturally provide them with the beginnings of a microbiome — the body’s collection of microbes in the gut, on skin and elsewhere. Vaginal seeding involves collecting a swab of vaginal fluids from the mother and smearing them soon after birth on the skin of a baby born by c-section, with the aim of replicating this first exposure.

Studies have identified differences in the microbiomes of c-section babies and vaginally delivered children. C-section babies had higher levels of opportunistic bacteria — those that circulate in hospital — in their guts in the days after birth, and, months later, tended to lack common gut microbes that would support immune function.

In 2016, a team co-led by Clemente published a trial of vaginal seeding: four infants who underwent the procedure successfully acquired microbes from their mother’s swabs and had microbiomes that resembled those of children delivered vaginally3.

Although the study did not look at the long-term effects of vaginal seeding, the findings led to an avalanche of interest in the procedure, says Clemente. In 2017, the American College of Obstetricians and Gynecologists expressed concern that vaginal seeding could transmit pathogens and recommended that the procedure be conducted only as part of clinical trials.

Developmental advances
To better understand the safety of vaginal seeding and determine its potential benefits, a team led by clinical scientist Yan He at Southern Medical University in Guangzhou, China, recruited women who were due to deliver via c-section and randomly selected them to have their newborns exposed to either vaginal swabs or sterile saline.

Women were first screened for numerous infectious diseases that could threaten the health of the babies — including COVID-19, because the trial was conducted at the height of the pandemic. Babies who received the vaginal swabs developed no serious health problems, and had similar rates of non-serious complications, including mild skin conditions and fever, as the babies swabbed with saline.

When the babies were three then six months old, the researchers asked their parents to fill out a checklist of neurodevelopmental milestones in communication, movement, problem-solving and social and personal skills, such as reaching out for toys and smiling at their reflections in a mirror. The infants who received the vaginal swabs tended to reach slightly more of their milestones than did babies swabbed with saline.

“It’s very exciting and promising,” says Alexander Khoruts, a physician-scientist at the University of Minnesota in Minneapolis. But it’s not clear whether the neurodevelopmental differences will turn out to be meaningful, because the brain changes so much as children develop. “Early delay by a couple months may not translate into anything meaningful at 18 years.”

Lars Engstrand, a clinical microbiologist at the Karolinska Institute in Stockholm, is reassured by the safety of vaginal seeding, but only if the mothers are screened for pathogens. “That is a really important message to clinical researchers in this field.”

Encouraging results
He agrees that his team’s results should be taken with a grain of salt. “I don’t think our data now has real clinical significance to say ‘yes, you should do this intervention’,” he says. Rather, he says it gives him the confidence to embark on a larger and longer-term study that will ask whether vaginal seeding affects rates of neurodevelopmental conditions such as attention deficit hyperactivity disorder and autism spectrum disorder, which population-health studies suggest are more common in people born through c-section.

Other clinical trials are also trying to pinpoint potential benefits of vaginal seeding. Engstrand and his colleagues are measuring its effect on a skin condition called atopic dermatitis in around 300 participants. Clemente is also part of a US study that is looking at allergies and asthma, and a team led by Maria Gloria Dominguez-Bello, a microbial ecologist at Rutgers University in New Brunswick, New Jersery, is looking at its effects on obesity.

Vaginal swabs are not the only way to alter the microbiomes of c-section babies: a 2020 study found that giving newborns diluted faecal samples from their mothers led to gut microbiomes that resembled those of children delivered vaginally. Khoruts says that such observations should stimulate researchers to identify the specific microbes transferred during birth. “That’s what the next steps have to be.”

Paper Writeup

 
Laos cave fossils prompt rethink of human migration map

A skull fragment and shin bone suggest that early modern humans might have passed through southeast Asia earlier than thought.

Archaeologists have uncovered two new bone fragments in a cave in northern Laos, suggesting that Homo sapiens wandered southeast Asia up to 86,000 years ago. The findings, published this week in Nature Communications, indicate that humans migrated through the area earlier than previously thought.

Over more than a decade, excavations in the Tam Pà Ling cave have uncovered seven bone fragments sandwiched between layers of clay. Laura Shackelford, an anthropologist at the University of Illinois Urbana–Champaign, and her colleagues have regularly had to hike through sticky tropical heat to reach the mountain-top cave.

After digging 7 metres down, excavations have finally hit bedrock, and the team has been able to reconstruct a complete chronology of the cave, says Shackelford. Sediment and bones unearthed in the cave show that modern humans have inhabited the mountainous region for at least 68,000 years, and passed through even earlier.

“I can’t overestimate the importance of having another point on our map for early modern humans in southeast Asia,” says Miriam Stark, an anthropological archaeologist at the University of Hawaii at Manoa who was not involved in the work. “Understanding southeast Asia is critical to understanding the world’s deep history,” she says.

Old bones

The newly discovered bones are a small piece of skull and a shin bone fragment. The remains were probably swept into the uninhabited cave during a flood. The researchers dated herbivore teeth found alongside the human fossils using electron spin resonance and uranium-series dating. They also estimated the age of the cave sediment using luminescence dating, which calculates when photons last illuminated the soil. Together, the results put the ages of the skull fragment and shin bone at around 70,000 and 77,000 years old, respectively. But the shin bone could be as old as 86,000 years. That’s much older than the first fossil unearthed at the site more than a decade ago, a chunk of a skull estimated to be 46,000 years old2. It’s also older than other cave bones — two jaw fragments, a rib and a foot bone — that are between 46,000 and 70,000 years old.

Fossil records in southeast Asia are limited, in part because the tropical climate decomposes most bones. The details of when early humans first arrived in the region, where they came from and where they migrated to is still a matter of debate, Shackelford says. Laos lies on a potential migration route to Australia, where the oldest archaeological site is around 65,000 years old. In addition to contributing data to an understudied area, Tam Pà Ling provides further insights into the timing of migration through the region.

Some human migration hypotheses use DNA analysis to argue that H. sapiens dispersed in a single rapid event after a geological period, called Marine Isotope Stage 5, which lasted from 130,000 to 80,000 years ago. But the Tam Pà Ling fossils don’t align with these models. Instead, the fossils suggest dispersal occurred before Marine Isotope Stage 5 had concluded.

“We’re seeing something different,” Stark says. That doesn’t mean that the genetic models are incorrect, she says, just that the picture they reveal is incomplete.

The shape of the Tam Pà Ling fossils further complicates the story. Although they are from H. sapiens, the youngest bone — the 46,000-year-old skull fragment — has a mixture of characteristics of both archaic and modern humans, whereas the oldest fossils have more-modern features. For example, the older skull fragment lacks the pronounced brow bone associated with more-archaic humans that is observed to some degree in the younger fossil.

That is counter-intuitive, Shackelford says, and suggests the older fossils might not have evolved from local populations, but rather represent groups of early modern humans that migrated through the area. Armand Mijares, an archaeologist at the University of the Philippines Diliman in Quezon City, says that this is a plausible interpretation, but that more evidence is needed to be certain.

Shackelford and her colleagues will continue excavations in the cave to look for more fossils. They are also trying to recover environmental DNA from the clay, which could provide clues about what flora and fauna were living in the surrounding area tens of thousands of years ago. Discoveries beyond the cave could also yield valuable insights into the early human inhabitants of the region.

“This is just one mountain,” says Shackelford. “There are thousands of caves to explore.”

Paper Writeup

 
This is interesting, if you're into the social sciences:

Fortune, 17 June 2023 - "Pew Research Center is tired of blaming Gen Z and millennials for everything—it’s retiring the whole concept of generational framing"

Ah, shoot. That's behind a pay-wall. I read it earlier, but now it's all blurred-out. I can't cut & paste anything. Well, here's the press release:

Pew Research Center, 22 May 2023 - "How Pew Research Center will report on generations moving forward"

Pew said:
Pew Research Center has been at the forefront of generational research over the years, telling the story of Millennials as they came of age politically and as they moved more firmly into adult life. In recent years, we’ve also been eager to learn about Gen Z as the leading edge of this generation moves into adulthood.

But generational research has become a crowded arena. The field has been flooded with content that’s often sold as research but is more like clickbait or marketing mythology. There’s also been a growing chorus of criticism about generational research and generational labels in particular.

Recently, as we were preparing to embark on a major research project related to Gen Z, we decided to take a step back and consider how we can study generations in a way that aligns with our values of accuracy, rigor and providing a foundation of facts that enriches the public dialogue.
Pew said:
We’ll only do generational analysis when we have historical data that allows us to compare generations at similar stages of life. When comparing generations, it’s crucial to control for age. In other words, researchers need to look at each generation or age cohort at a similar point in the life cycle. (“Age cohort” is a fancy way of referring to a group of people who were born around the same time.)

When doing this kind of research, the question isn’t whether young adults today are different from middle-aged or older adults today. The question is whether young adults today are different from young adults at some specific point in the past.
Pew said:
When we do have the data to study groups of similarly aged people over time, we won’t always default to using the standard generational definitions and labels. While generational labels are simple and catchy, there are other ways to analyze age cohorts. For example, some observers have suggested grouping people by the decade in which they were born. This would create narrower cohorts in which the members may share more in common. People could also be grouped relative to their age during key historical events (such as the Great Recession or the COVID-19 pandemic) or technological innovations (like the invention of the iPhone).
 
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Wiki has a great write up on all the various generations and sub generations.

 
Is this the right thread to talk about the lost submarine?
I don't see why not. Hearing about how this particular sub was built and operated, I couldn't help but think of the episode of Rocket City Rednecks where the guys tried to make a submarine out of a refrigerator. As they launched the thing into a lake, the one of them who wisely chose to remain ashore leaned back in his folding lawn chair, popped a brewski and said, "Good luck. Hope y'all don't die er nuthin'." I think this sub was slightly more seaworthy than that one was, but it still sounds like a deathtrap to me. I actually don't know how many voyages this one undertook before calamity struck, and of course we won't know what happened to it for a while. I heard one person say that it could've gotten snarled up in a free-floating commercial fishing net, which can be a mile long. I suppose there are any number of things that could have happened that had nothing to do with the design of the sub, or was related to some sort of malfunction. Still, it doesn't sound like they went down there in some sort of modern Nautilus.
 
I have some sympathy for the tourists in the sub, but I can't find any for the owner. Anyone who considers safety regulations as an obstacle deserves nothing more than to see exactly why those regulations exist.
 
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