Some more thoughts on the Seleucids:
Money is really, really tight in the beginning. I start with setting research to zero. Some cities produce workers, other fairgrounds, a few barracks/archers to act as defenders. Army is sent towards Egypt. The Pyramids, newly added (haven't seen it before today's svn), can be built in a single turn, surely something is odd with that?
Early war with Ptomlemaios allows easy capture of Jerusalem, and eventually all of Egypt. I gained a relic from Jerusalem, but not sure of what to do with it.
I hired a horseman as a mercenary, but it didn't turn up until 10-20 turns afterwards.
Rhodes spawn in the water.
The prebuilt roads to Anatolia certainly makes it easier now.
The Romans now spawn with war, which is good. One of the previous tries I managed to get them to open border and wander through my empire to do war against the Bactrians, which felt like cheating.
Due to the changed city placement in Anatolia, the Armenians have now built Trapezus, which requires conquering. That makes the Seleucid UHV harder, was that intended?
Greece is captured fairly easily, so by 246 only Trapezus remains, but I still feel stressed. The empire is unstable (-27 stability), and I don't know of a good way to boost stability, so the Ptomlemids might declare independence any minute. Luckily, the Armenians are friendly and make peace immediately after Trapezus falls.
Then, however, a Roman stack of doom approaches Salonika. It has 8 legions, and I only left my two war elephants and a spearman in Greece. I cheat by giving away Salonika to the Armenians. I think the Armenians should not accept cities in Greece (like the Mauryans won't accept any city except Herat).
With collapsing economy, every city runs wealth, and I am still at a deficit. Having the mercenary (57 gold to buy, 3 gold upkeep for quite a while) was a bad idea!
The pirate galley massacres my fishing boats, as the fleet was disbanded due to lack of funds.
Several resources in Egypt (dates on flood plains, stone on hills) are inaccessible for workers, is that intended?
The Parthians start with huge stacks, and force you to move troops to Ecbatana. It is frustrating that they flip, but at the same time good - you are forced to keep enough defenders, which will give them another boost. Not sure if I should've refused the flip.
Some of our forces are joining the enemy, even though I refused the flip. Is that supposed to happen?
Egypt did eventually revolt, in 148. I let them go.
Romans declared war again the turn after Egypt revolted (were they scared of my might before that?). Conquerors spawned in the middle of Anatolia, at Trapezus. That was really unexpected, as I had already met the Romans once, and thought they wouldn't get a second conqueror event. As Trapezus fell, the UHV of not losing a city failed and I lost my fifth try. At that point (142 BC), I was at 26/50 for my third great general, so if I just had survived without losing a city, it would have been accomplished easily.
All in all, a fun try. The Roman legionaries are really scary! I think I should've made peace with Parthia as soon as possible and only left defenders. As it happened, I had placed my main army in Iraq, to reconquer the Parthian lands, which left the rear open for the Romans.