Did someone check for wonders?
Where is the great lighthouse? That would be a keeper in my humble opinion.
Toku Built it, where? we don't know yet. I think we should forget about great lighthouse, as Toku is too strong to get at present.
Did Isa build the temple of Salomon? Not sure it's a good reason to keep a city, but here is my point :
Well, it's in Seville. But as you know there are not too many Judish Cities (just 7%), Temple of Solomon is just gonna provide us 3-5 gold I believe. Well, something is better than nothing.
We're too late for a good conquest game. At this time we should have won already, so we're certainly going nowhere this way.
I don't think we should leave our hope right now. This map/game is designed this way that all the teams would be having similar problems. When I posted my save, SGOTM page gave status of all the teams. It's a good news that we are not worst.

Some teams got a sudden decrease in score, I am not sure what was the reason, but I believe whether they lost some cities, or were stuck with the gold problem.
Is domination an option now or not?
If it is, we may go for a total destruction of Isabella while keeping most of her cities.
We should go for Conquest. Domination will require too much support for army and maintenance. Well, whatever will be achievable first, we can do that. But I recommend we go for Conquest, as this is faster and achievable without too good scientific knowledge.
This would mean growing cities around mecca, planting our culture bridges asap and building up defenses (=happy units) for a while after taking out isabella.
Well, we need culture bridges, but I don't think we need anything in the Arabic Island. There is just Thundra, Ice & Desert there for new cities. Mecca is the only site with good terrains, and we got that.