Alright, I've played up to T48. Pottery has been researched, and I've made a start on Animal Husbandry:
Barbarians are actually starting to appear now; my warrior in the west killed one while defending. Only warriors for the moment, but the lack of AIs means I don't have enough troops to effectively fogbust the entire south and west, let alone the north. I'm thinking I should get at least a warrior or something in Osaka.
I settled Osaka, going into slavery while my settler was in transit. Theoretically, I know that's always a good moment for revolt, but I don't always think of it myself - thanks for reminding me, krikav. I've chopped into the granary in Osaka, and my new worker got a chop into the second settler in Kyoto. This worker will now start chopping for a workboat in the new city; if I calculated everything, he'll be one turn early, so there will be one turn of idling in the forest before the city actually gets founded. It's not elegant, but I think at this point it's the most efficient way of getting city 3 started as quickly as possible.
Production-wise, I think it would probably be a good idea to whip the granary now in Osaka. As I understand it, it's generally good play to put overflow into workers/settlers, but I'm not sure if that's what I should be doing in Osaka at the moment - I think barbarian defense is something I should be worried about as well. Kyoto can finish its settler, but I'm not sure what I should build afterward. Probably another worker or settler, but which one first? A worker would be nice if I'm going to start cottaging Kyoto. Furthermore, I think I need another worker to immediately begin improving new cities once they get settled.
Speaking of which, I find it hard to determine the next spot for settling. My scout has been scouting up north, but there is literally no food to be found there:
There's a lot of wine, though, and copper to the far north. In any case, I think my best site for now is on the western coast, near the wheat there. I'm still unsure of where exactly to settle there, though; go for a coastal city, or grab at least a few inland tiles? Those inland tiles are pretty poor, though... Alternatively, I could settle near one of the deer in the south, but those seem like pretty poor sites, even with the river. I'm also thinking of a city 1SE of the western wheat, which would have deer in the second ring and be coastal... But for some reason that doesn't strike me as optimal play.
In any case, I'm really hoping to meet an AI sometime soon as well. And I really don't know what to do with all that poor land up north...