I finished a game after an awesome 15 hours strait (shh I know, I'll be running a mile tomorrow) I played a 10 civ 20 city-state continents map with all the new civs and France.
Big borders are nice, four cities effectively shuts off an entire corner of a continent allowing for peaceful expansion of you place the cities right. Also the pathfinder kix butt! picking ruin bonuses is the perfect way to get that snow ball rolling. social policy at turn 5! comp bow at 7 and pantheon at 20. I had the first religion, and a stack of gold from all the barbarians I killed. (I'm new at explaining strategy so be patient)
It is possible to easily be the richest civilization in a game before any caravans or cargo ships come online, first monument, then use your pathfinder to find a ruin and pop for culture. This should get you policies around turn 5, then pick honor to start off. Make another pathfinder and upgrade one into a comp bow. Then go barb hunting, I not only got 200+ gold, I also got enough culture to get a nice start on liberty (I never finished honor, I only took the opener, very doable now with reduced costs) also if you are lucky with CS quests this can get you very early allies. I had Jerusalem allied by T 50. (I might put up a more advanced guide in the proper forum, but for now more experiences and opinions)
As the game progressed my UU and UA were less useful the Shoeshone will get a player set up in the early game, its up to you to take advantage of the push.
In my game I had the new Mt Kilimanjaro right next to me, its bonuses are not to be ignored, pathfinder with altitude training (the bonus Kilimanjaro gives) are game breaking, a hill I was became a road for my scouts and mounted units, but the combat bonus is nothing special.
The new culture is extremely good with one exception: the inability to swap different types of art (ex my MONA LISA for your THE RAVEN) with archaeology I could always keep my musieums filled and themed, so that part of the swap gets an A +, but then I had all these empty opera houses and broadcast towers, so maybe a way to trade paintings for books or books for songs. Maybe even gold for them (like 400-600, lots). But I say that the culture side is now so flavorful seeing the theme bonuses increase I felt like I was making super popular museums, if only we could make museums of science.
And The trade and Ideologies feel some much more real and engrossing, the last person to pick sides was super rich, venice (he also had the most delagates) who was equally friendly with me (freedom) and Portugal (order) and his choice effected the whole game. That is the first time an AI has made a decision that affected me other than dows, and it was great! Speaking of AI's they now understand bombers and how to use them, Shaka targeted my artillery and then played it safe when I had interceptors, maybe Japan got a buff of the zero now being usefull and needed? well see, after all this one only one game. but what I saw, this is civ as we have always wanted it, and after the balance patch, civ V will be done in my eye...missing nothing, this is the full package

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