About permanent settlement on Mars - wouldn't weak gravity be a major obstacle for creating it? I read somewhere that people who spend long time on space stations, like a year or so, had serious health complications. And that were trained professionals. Imagine now people spending decades, or even born on Mars. Other problems are at least technically solvable, we can bring supplies, shield the base from radiation, etc., but what we can do with near weightlessness?
Yeah it's the #1 problem in my opinion. You hit the nail on the head - everything else is a 'solved' problem more or less in that they mostly just take money and willpower to overcome. Reduced gravity is another thing altogether. We have a bit* of data on weightlessness and a ton of gravity on 1 g but no data on .3 g. We really have no idea how bad it will be long term - especially for babies born there. The ISS was intended to have a centrifuge lab to test this stuff in animal models but it was cancelled. There are no plans that I know of for <1 g test labs in orbit so likely the first data we'll get will be when people start going over there which is bad.
In science fiction they often get around this through drugs or one-person centrifuges that people use daily to strengthen their bones but who knows if that will be sufficient. Also, the trip out to Mars doesn't have to be super long and people can cope with a few months of weightlessness. But for some trajectories you're talking 9+ months of one-way travel which would be pretty detrimental.
*Despite decades of spaceflight, the vast majority of our astronauts have spent less than a month in space each and there have only been a few hundred astronauts in total. Thus the data set is so laughably small and incomplete that its hard to draw a lot of conclusions from it. There are a lot of things we do know but without more data I don't think we can make a lot of definitive statements on the long term effects of <1 g other than it's generally bad for your body.
I think that health problems would come mainly from radiation. Low gravity is not very problematic as long as there is some. Problem is zero gravity.
Like I said above, we actually have 0 data to draw the conclusion that low gravity is fine. Given that only a dozen astronauts have experienced less than 1 g on the Moon (and only for 2-3 days at max), we really don't know anything about what it would do to our bodies.
Only 1000??? So 3-4 heavy launches? So ,the cost of 3-4 big airliners o a bunch of fighters?Inconceivable. We should have cities in Titan already.
Well that's why it's a WAG. I'm also looking at the problem from a minimum viable product viewpoint - so I'm trying to think of the minimum mass it would take to set up 3 or 4 people to live on Mars indefinitely. If you are interested in a bigger population then let me know and I'll adjust. But here's the partial set of assumptions I'm working from -
I'm thinking of an initial colony of just 3 or 4 people that could live indefinitely. The colony could grow slowly after the initial set up phase but the colony would self sufficient such that those initial people don't need anything else from Earth to live and so long as the transfer rate of new colonists is slow, they can continually add capacity to the colony through sourcing of local materials to allow for slow, controlled growth through immigration and organically. Most of the stuff they will bring will be excavation equipment and the vast majority of their raw material inputs will have to come from Mars itself. I'm also assuming they land in a relatively rich area with easily-accessible subsurface water and useful mineral deposits. Also, every piece of equipment they will bring will be mass-optimized, so I'm assuming a ~50% across the board cut to the mass of things like excavators.