Actually No. All Diseases end at Smart Drugs and Regenerative Medicine. And as such Crime should also start ending somewhere in the later Eras like Cosmic Era. The constant increase and expansion makes for very poor end game play. All the Property systems need to have endings. Else the Mod never really has any ending other than Total Conquest which can be achieved Long before the later Eras come into any meaningful play. In essence all of pepper2000's additions become a wash because of this design philosophy to make the Mod totally war centric.
I played it as simulation and exploration more than standard war game on my AI-less space map.
Similar stuff can be said from mod internal reality perspective:
This is not a story, that Luddite would tell you, properties (except Education and maybe tourism) are dead.
Starting from Information era humans starts getting merged with technology - maybe to stay competent with AI or to be able to colonize places normally not colonizable, or to extend their abilities.
It is in background of space exploration, one of
@pepper2000 thingies.
At first its stuff like Digital Lifestyle or Digital Identity - basically more and more stuff can be done trough internet and there are social media and various forums.
In Nanotech and Transhuman era you have cybernetic implants and genetic modification. If you ever saw sci-fi stuff, then you have some sort of idea how it may look - basically humans are improving themselves with technology, but still are humans.
Here Robocop, Batman and Spiderman says hi - some of their powers could be replicable before travel to stars is possible.
All pests could be obsoleted here.
Here some cimes can be obsoleted and pollution can be replaced with buildings (few pollution pseudobuildings are actually replaced with buildings in second half of game.
In Galactic era humans can convert themselves to nanotechnological robots. This means goodbye to old biology.
And goodbye to pollution in later part of Galactic era.
Terminator or Optimus Prime are creatures like this.
Even ultra high tech star dust is still star dust.
Most crimes of old are obsolete and there are new crimes.
There comes Cosmic era.
Molecular stardust is old fashioned - femto, pico all way to zeptotechnology are available during course of that era.
Pests, disease and pollution simply don't exist anymore.
Computers are so powerful, that you can store yourself as information and basically act as game character with all super powerful toys, but unlike current games you can transfer your stuff between them.
All old crimes are obsolete, but there are still some crimes mainly all sort of breaking Prime Directive like building pyramids in some ancient civilization or trolling Information era planets.
And then there is last Transcendental era - here each post posthuman can essentially recreate any fictional world, that ever existed in reality.
Reality is basically plaything.
Basically any show can be shorted to: "Trascedentals did it or recorded it (except ones in our universe

)"
Last three eras require Faster than light travel, Time travel and few others stuff to exist, that may be actually impossible to do in our universe.
While Nanotech and Transhuman may be hard and realistic Science Fiction, Cosmic and Transcendental are more like techno fantasy and backstory to lore of many fantasy worlds.
Education should be only property, that survives to end of tech tree, as it represents technological competence.
As for tourism, as this represent population flow it could exist to end of time.
Pests and properties like water/air pollution would be eroded when humans don't depend on their environment anymore and crime would drastically change (and reduce to couple max ten or so of pseudobuildings) its nature over second part of game and then go extinct somewhere in transcendental era.
Basically increasing acceleration of technology should crush properties and food related stuff sooner and later.
I like SF and Fantasy stuff, so what was "(Kerbal) Pepper Space Program" on beginning it turned into Final Frontier Fantasy, where instead of being character in fantasy world like Skyrim or watcher/reader of Harry Potter you pretend to see them created, when you build that "Fantasy City" or "Layered World" late game buildings, that you make in space cities.
As for Human Mod culture bonuses - they represent technological evolution.
As for Creativity yield - it soars to divine levels following technology.
TL;DR
I had a lot of fun with Information+ eras.
Game can switch objective from conquest/domination/cultural/diplomatic victory to science/space mastery somewhere in Modern - Nanotech era.
Players end up assimilating Earthly AIs by Galactic era and there would be barbarians in various space zones representing aliens.
Pests and Pollution should be inexistent in Galactic era or be something different and depedant on map zones by that era,
Crime pseudobuildings should be thinned from 76 pseudobuildings to less than 10 in Galactoc/Cosmic era and be overhauled in their kinds and be locked to certian map zones.
Education and Tourism can last forever.