Do you automate workers and citizens in cities..

[Thrar]

The only worker automation I use is build trade network, once there is nothing important to build any more.

I automate citizen assignments as much as possible after the very early stages, I'd say about 80% of the time. If you don't automate, you have to be sure you check every city's assignments whenever there may be reason for changes, such as growth or a build item finished.
I don't have the discipline to constantly do that for more than 3-4 cities and if you leave them unchecked in the wrong moment, you're going to lose much more than a slightly sub-optimal governor assignment would cost you.
I do however still go look over my cities regularly and optimize e.g. to save a turn of growth or build time, either by selecting the right governor option or, if necessary, manually.

I never automate build queues or worker tile improvements. In the late game I group workers and set longer build queues in cities so I don't need to go through everything quite as often.

 

[guspasho]

Citizen automation isn't as bad as worker automation. But the city governor will occasionally do something stupid like working a plains hill mine instead of a riverside grassland hill mine when either mine finishes the item in queue on the same turn, but the grassland mine helps you grow faster and brings one extra commerce.

It is best to cycle through all your cities at least once every couple of turns to correct such stupidity and to fire those damn Spy specialists the governor seems to want to hire everywhere!

OMG I hate those spy specialists! Why won't they run something useful, like merchants or scientists, or an engineer? And then I pop a great spy! Argh!

I can't micro all the cities in large empires to keep the governor from trying to run spies. Is there a mod or a fix of some sort to this?

 

[Frukthandlarn]

I automate my workers late game when my main cities have improvements and stuff. Important to uncheck the worker ability to destroy already buildt improvements. You don't want them to ruin what you have done.

Citizens I automate mostly when it comes to producing specialist or to precent growth or when I want a citi to maximize its hammer output.