Finding it hard to balance science, production and culture. How do you guys do it?

Don't forget that a city can have tons of trade routes coming out of it.
 
Can you change the trade route origin/destination when you want? If so you could distribute your caravans as needed dynamically: city start up, wonder building, pop explosion etc....
 
Can you change the trade route origin/destination when you want? If so you could distribute your caravans as needed dynamically: city start up, wonder building, pop explosion etc....

Nope only when the duration runs out or when you build/buy a new one.

For the purpose of balancing things I'd go for commercial first for everything. It gets you more gold and more trade routes which are key. if possible build on a river at the coast where you can place an adjacent harbor for even more goodness. Gold is really useful to have. With enough you can build your army with ancient units and then cash upgrade to modern. One trick is if you skip the tech that gets you pikemen you can build spears forever. Then after you've made enough you can research the pike tech and then upgrade to AT guys, with the professional army card its like 245 gold to get you an AT guy.

Another thought is to have a large army of obsolete but low/free maintenance units and enough cash reserves to upgrade at a moment's notice. If there is no war you have a free military/swarm of fogbusters. If you get DoW'd you can spend the cash to access your government cards, swap in the professional army one and mass upgrade into a modern fighting force and fight without war weariness.

Gold also lets you buy things at small cities rather than spend forever trying to build things that can be bought.

For production you need a nice triangle of cities where the factories and zoos can all affect each other.
 
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