Joebasalt13
1. Probably some antivirus software prevents you from editing 'Harkonnen.ini' or something keeps it open. You may try also download .zip file (check post #1 again, I've modified it several minutes ago).
2. It does not matter, but if you use 'insane_mode = 1' (Harkonnen.ini), you might have problems when alt-tabbing back into game. Most people get black map until it's updated, but I think this can lead to more serious problems. Basically, if you plan to alt-tab oftenly in full-screen mode, you should use 'insane_mode = 0', but this assumes that you can edit it...
3. 360Mb is something maximum when it fits 512Mb without swapping, but later in your game you will probably need more RAM. Also, 'insane_mode = 0' needs 80-100Mb more RAM, so to make 'insane_mode = 0' transition without loosing performance, you will surely need that upgrade. And after all, most games today require 1Gb to play well...