Let's see. The Roman Empire is unstable right now, and could be tipped to collapsing rather easily. The Kushans are being lazy, but it looks like Rome is at war with them, and have even taken a city, so that might be influencing it.
Looking at game in general, the Mauryan snatched up all of India and then collapsed in 190BC. There was a decently powerful Armenian empire, that stretched from Byzantine to Persia. Egypt went to war with Armenia though, and Egypt won, and became very powerful as a result. Egypt then went to war with Parthia, even taking their capital, and Parthia collapsed in 25BC.
Egypt went on an eastward conquest, taking most of India, and even started heading toward China after taking over the Tarim Basin, before they collapsed from over expansion in 38AD. All that was left now was an interesting but scattered Sabaean Empire, with cities in Africa, Persia, and even India, that collapsed soon after.