DRJ
Hedonist
The new solar systems would take a very long time to get to which would mean time between your home planet and them would be a long time. Such isolation could lead to possibly the beginning of new species. Ones adapted to space, ones adapted to each of the planet colonies, etc.
I mean this really becomes the limit on how complex you want to get and how far can we imagine into the future.
I mean I am sure we can fully fill out all the home solar system exploration and colonization but beyond that I am not sure. Because it eventually just becomes un-realsitic fantasy.
Maybe here comes the Omega-Point-Theory of Dr. Tipler in place. It is the most spaced out theory I ever read. Can't say I believe it or anything. It's just mind-blowing stuff... the perfect last mission to achieve in RoM transhuman aera!
http://en.wikipedia.org/wiki/Omega_Point_(Tipler)
http://en.wikipedia.org/wiki/Self-replicating_spacecraft