I forget if this was mentioned before, but I'm going to have to go with whoever said there's no real "optimum".
Ideal conditions change from place to place and from time to time. Sometimes it's drought tolerance. Sometimes it's insects. Sometimes it's nasty chemicals. It's pretty much impossible to engineer an organism ideally defended against everything, seeing as how Mother Nature has been trying and failing at that for a few billion years.
Plants need water, fertile soil, not to be eaten by pests... These can all detract from growth. If a plant is resistant to these things, then, as you say, it will perform better in their presence than another plant that is not.But isn't that the point of a double blind study? To determine exclude extraneous variables and get at very basic qualities.
However, the very act of making a plant resistant to them rather implies that they're not optimal conditions.
Hence using that same plant and comparing it to one that isn't burdened by resitance mechanisms is the same as comparing an experienced hiker with rucksack and comparing him to a sprinter. He can cope with all sorts of problems on the way, but you're not giving either person any problems, so the sprinter seems better.
My point was that the result of such a study is mostly meaningless. The real question is the prevalence of disease and so on, and the relative levels of resistance.