I doubt it. The human brain just doesn't have enough data storage to generate the world around us. Also with people born with mental disorders and suffering brain injury, you'd think our reality would just disintegrate. Not to mention being drunk or high! Then we would actually be able to fly when on a trip! But we don't, hence why it's a bunch of b.s.
It is a bit naive to think that physicist philosophers mathematicians etc haven't had in mind all those considerations before, but i applaud your intellectual honestity.
I think the problem is that you are getting it all wrong. It is not about the human brain, but about how things really happen.
At quantum mechanics sizes any observation is a meaningful interaction between the observer and the object. To know a quantum property you need a way to see it, for instance looking at it. Macroscopically, looking at something means that your eye is receiving countless photons after they have interacted with the observed object. This is not an issue since photons are tiny and macroscopic object as a whole are huge, so they will not be meaningfully affected by the photons we have used to observe it. (Unless we are using X or gamma rays which could toast anything but that is other story)
Problem is that when speaking of atoms and fundamental particles individually we are at such a tiny scale that interacting with a simple photon will change the property you are observing. For instance the spin of an electron will change if you use an photon to observe it. It would be like trying to know the position of a pool ball hitting it with another pool ball.
All this seems pretty silly, but if you think it more carefully you will realize it is not, because there is not any way to know anything about anything in the universe without interacting with it somehow, and since at a microscopic level any interaction will altere the properties of the observed object, it is the very observation that will define the properties of the object. It is key to have in mind that there is not a more fundamental reality under it you can hold to, we are at the fundamental level already. For any effect particles are not defined until you observe it. It doesn't not even make sense to speak about the state of a particle before you observe it. Going even further they really have not a defined state until you observe it.
There is no way to realize the consequences of this and other quantum mechanics principles and really understand how deep the rabbit hole really goes without understanding the underlying mathematics, which predict all sort of weirds behaviours, like particles appearing from nothing, having two different natures at the same time, or being in infinite places simultaneously, or particles 'affecting ' other particles kilometers away without any interaction, among many others.
Most amazing thing is that all these weird predictions, direct consequence from the basic principles of quantum mechanics, have been proven true experimentally and are considered irrefutable scientific laws. In fact many direct consequences of quantum mechanics can be observed by us in our daily life, like the laser of a DVD or the screen of any TV, or even more fundamental things like sunlight, or chemistry, or whatever...
