Instead of wishing since I don't know enough about strategy, let me speculate...
Hmm, given the trends in the most recent patches of 4 and 5, I expect the following:
-- The Holy Roman Empire has been deemed overpowered, due to its 75% reduction maintenance building and a unit that gains bonuses against TWO unit types. This is clearly too much, and thus now HRE starts with no starting techs.
The game will not be updated to tell you the changes. Wonder why you can't build that road? NOT TELLING.
-- Inca and Rome has been removed from the game, due to player abuse.
-- Barbarian naval units were not effective enough, thus Galley rate is doubled and Triremes may spawn.
-- We have decided that diplomacy has been far too simplistic. Thus, AI leaders will find stupid and petty reasons to hate you now including "You beat us to a wonder", "You are pursuing the same victory as us" and "You are a warmonger despite we are too". The display will not be updated to display these new changes, because we thought it would be better to figure it out yourself. Besides, isn't it funny and surprising to have a friendly civ attack you?
-- Founding religion was found out to be an overpowering strategy. Thus, religions no longer autospread.
-- We found it impossible to win with the Apostolic palace, thus that building will autospread, and you need only 60% to win now. Also, defiance anger increased to 10. That'll teach you to defy them.
-- Deity has been corrected to "Diety"
--We discovered an exploit where players have been begging the AI opponents for 1 gold to ensure a peace treaty. This has been removed.
--Automated workers automatically suicide into enemies. Nothing has changed.
-- The route to function will cause workers to randomly build roads in the wrong direction. This will ensure that players will put more focus into micromanagement
-- Replaced the Aryan Barbarian uprising with the "Alien Abduction" event. This will cause all your cities and units to disappear to suffer a horrible fate of alien experimentation. You will instantly lose and have to start a new game. We figured we'd save 5 seconds of your time doing the same thing.
-- The Nuclear Power plant has been rebalanced. Now, all power plants will randomly explode.
-- When a AI peacevassals to another. The game will tell they formed a permanent alliance, even if they aren't enabled. We figured we'd be honest about this.
-- Increased trading with worst enemy penalty to -20. You should really watch out for who you trade with.
-- AIs will keep track of techs in fear of you being too advanced, even if they don't know you. This was done to be consistent with the worst enemy mechanic.
-- You no longer receive gold for failing to build a wonder. We felt players were abusing the gold beyond its intended purpose.
-- Only one military unit may occupy a tile. However, the AI has not been updated to reflect this.
The best thing about V was that it made me appreciate IV more
