America, Egypt, India, and China are already in, so they are obvious picks. 14 left. The rest assumes they don't pull a shocker, like initially leaving Spain out of Civ V. It would be weird to have a world domination history game without France, Spain, England, or Russia. 10 left. (Altho Spain was shockingly left out of Civ V Vanilla, so maybe I am wrong here.) Greece and Rome are more or less required for same reasons as above. 8 left. The Civ series has always shown great preference for including the Aztecs. 7 left. The Middle East likely will be in there somewhere. Probably 1 or 2 civs total. Arabia, Persia, and or the Ottomans, with no particular one being more likely. Of the remaining 5, I would predict one additional South American civ (Maya or Inca), one North American civ (this is a total wildcard), one additional African civ (Mali or Ethiopia), and one east Asian civ (Korea being a likely pick). My main reason for feeling this way is the graphics engine in Civ 6 will make them want to distribute the "flavors" of each nation more or less evenly.