Unless it's something like For Better Or For Worse. Some of them were one-shots, but most were part of a storyline that went on for decades. Lynn Johnston only retired due to physical disability (some medical issue that affected her ability to draw); otherwise she probably would have kept going for a few more years.
Some of those storylines were epic. If you want to unite a country, kill off the dog in their favorite comic strip. I still tear up when I think about Farley; it's like he was everyone's dog.
