Well it's not QUITE as easy as Major Tom makes it sound...bad leader, bad land, semi-isolation. But it's not totally dire as well.
Fippy is right when she suggests war - the area where humans have the most advantages over the AI. With bad land, going for space just won't work most of the time.
I took your starting save and played a couple of millenia, very sloppily and with lots of errors. Still don't have a single happiness ressource (though Monarchy will soon come in), and the capital doesn't lend itself to cottaging anyways. So I went for lots of bulbs, and built first the Oracle for Aesthetics (in 1760), then the Great Library, National Epic, and soon the Parthenon in the capital. While doing that, my other cities didn't have much to build, so they build every wonder available for fail gold. I'm still unsure WHAT exactly I'll be bulbing - I first thought of going for Astronomy (bulb Machinery, Compass, Optics, Astronomy) for trade routes and invasion but Toku was backwards enough that gifting him Aesthetics + Alpha made him Pleased and he opened trade routes, giving us that. So maybe I'll bulb towards Liberalism (Philosophy, Education, Liberalism) for Military Tradition or Steel instead, put these things onto a lot of boats, and go for Toku and then some other players. If Darius again grows as big as before, I would go after him last, and just overwhelm him with numbers from 30+ cities (and if all else fails, nukes).
The game isn't won by far, but I'll play on this week and tell you how it goes.