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[IglooDame]

I never log in to the application client..

Not specifically to the application client, but to your PC itself.

What operating system are you running? I can clarify based on it.

 

[ironduck]

WinXP - if it logs in it does it automatically, I was never asked for any info other than my username and team name when I installed the program. If it didn't display the little icon I would have no idea I was running the program (except it keeps my cpu warmer which I thik causes more crashes since I have issues keeping my computer cold)

 

[lost_civantares]

For the first part, I don't know, for the second part, I think if you copy the work folder, queue, and such (essentially everything but the executable), it might work.

Okay, thanks I'll try that then on the lower WU count computer.

And for another round of questions:
Is there a way to download work and transfer it to a computer not on the internet?

 

[Sophie 378]

Mwahahaha, I've found another protein folding distributed computing project! http://predictor.scripps.edu/
And I feel good about them; I've been using the http://metallo.scripps.edu/PROMISE/ database a lot for my dissertation. Have a look, anyone who'd like to try a different numbercruncher for the same sort of thing!

From http://predictor.scripps.edu/predictor_model.php

Why/How is Predictor@Home different from Folding@Home, both seem to be addressing the same objectives?
Protein structure prediction starts from a sequence of amino acids and attempts to predict the folded, functioning, form of the protein either a priori, i.e., in the absence of detailed structural knowledge, or by homology with other known, but not identical, proteins. In the case of the a priori folding, it is a blind search based on the sequence alone. Homology modeling first identifies other proteins of known structure with some level of sequence identity to the unknown structure and then constructs a prediction for the unknown protein by homology. Both approaches utilize multi-scale optimization techniques to identify the most favorable structural models and are highly amenable to distributed computing. Predictor@Home is the first project of this type to utilize distributed computing for structure prediction. Predicting the structure of an unknown protein is a critical problem in enabling structure-based drug design to treat new and existing diseases.
Protein folding studies and the characterization of the protein folding process are based on knowledge of the final folded protein structure (in Nature) and aims to understand the process of folding, beginning from an unfolded protein chain. The endpoint of these studies is a comparison between native protein (in nature). Analysis of the folding process too is a critical outcome allowing theories for protein folding to make direct connections to experimental measurements of this process. The Folding@Home project pioneered the use of distributed computing to study the folding process. Understanding the folding process is of significance in understanding the origin of diseases that arise from protein mis-folding, such as Alzheimer's disease and Mad-Cow disease.

In other words (I think), F@H works out the steps to folding, starting from a known 100% unfolded structure, knowing the final structure (maybe just the rough shape); while P@H starts from the same place without knowing what the end result will be.

Oh, and another possible programme to run: http://fightaidsathome.scripps.edu/

 

[lost_civantares]

They seem to be having mechanical problems though which could get annoying at times, something that folding@Home hasn't seemed to have had.

 

[Till]

Warning: mysql_pconnect(): Host 'server' is blocked because of many connection errors. Unblock with 'mysqladmin flush-hosts' in /export/projects/predictor/html/inc/db.inc on line 16
Unable to connect to database - please try again later Error: 1129Host 'server' is blocked because of many connection errors. Unblock with 'mysqladmin flush-hosts'

Well... i vote we stay at F@H

 

[CIVPhilzilla]

Count me and my Winchester 3000+ OC'ed to 2.4GHz in. My user name for this is EdMcK515.

 

[Abaddon]

:welcome:

glad to have you Aboard

 

[BCLG100]

dont think we should start doing another program, will mean half as much interest in both.

 

[schmiddi]

Lost a months worth of folding yesterday: F@H was 10 frames before finishing a WU and suddenly experienced an error and deleted al data.

 

[Furiey]

I've had problems with power cuts that cause it to restart so I know how frustrating that is. I now take a backup of the folder every now and then (I try and remember every day but tend to forget) so that at least I don't lose everything if it happens again. Typically I haven't had a power cut since I started doing that.

 

[BCLG100]

I havnt really ever experienced anything like that.

 

[IglooDame]

I've had problems with power cuts that cause it to restart so I know how frustrating that is. I now take a backup of the folder every now and then (I try and remember every day but tend to forget) so that at least I don't lose everything if it happens again. Typically I haven't had a power cut since I started doing that.

Just a thought, you might want to look into a Uninterruptible Power Supply (UPS), ones suitable for protecting PCs against under-30-second outages run no more than US$50 or so and do extend the life and reliability of the computer (it wouldn't only be to help the Folding@Home bit).

 

[Furiey]

I have considered it, but at the moment just can't run to spending the money, it (as always) works out a bit more expensive in the UK. It's something that's on the list though.

 

[BCLG100]

bumpety bump, cant have this on the 2nd page, people might be put off by the incredibly long thread btw, its what put me off first time.

 

[Sophie 378]

We're at the top of page six now: 1320th. I bet we'll break into the top 1000 teams by the middle of Feb!

Meanwhile, have some more random pictures ... p53, a cancer-suppressor.

F@H on p53

DNA helix on the left, the p53 protein on the right. Source

p53 model. Source

 

[BCLG100]

have we had any new members?

 

[Till]

The two projects i am working on:

One of the trajectories from project638 has now come quite close to reaching the folded state. Structural similarity doesn't actually imply that this structure will complete the folding process. Here, we take this almost folded state as a seed and start new simulations to determine if the near folded state is in fact an intermediate, and how quickly it relaxes to the native state if at all.

Similarly to projects 1130-1133, these 4 projects explore the fleeting yet critical transition state region for transitions present for L939, the 39 residue fragment from the N terminal domain of ribosomal protein L9. To identify these structures as true transition states structures we must observe that half fold and half unfold. Unlike projects 1130-1133, here we study the barrier crossing at room temperature.

Can't say i understand much of that.
What strikes me as odd, is that both projects have the same graphic:

 

[Abaddon]

bumpety bump, cant have this on the 2nd page, people might be put off by the incredibly long thread btw, its what put me off first time.

I'll ask to start a new thread again soonish- but its a drag everyone changing signatures.. so i might edit the first post to link to any new threads saving you the trouble?

 

[BCLG100]

well i just dont have it in my sig as tbh i just dont generally click on links in anyones sigs