So far, I'm liking Warwick, Twitch, and Chogath a lot, for various reasons.
The game seems to have various inherent traits, which I'd consider to be "issues". Most notably, the focus on survival at all costs, and the complete lack of penalty for Fleeing like a Whipped Dog, leads to just about everyone turning tail and running when they're about to lose, and often depriving you of a kill.
As far as games are concerned, I'm personally more inclined to the "die with honour" mindset. LoL seems nice at first, but it isn't growing on me at all, and the more I learn about it indepth, and the elitist people who inhabit the most skilled inner core, the less it appeals to me,
There are a lot of playable champions, each with, as in FFH, their own unique take on the general gameplay mechanics. The difference here though is that only a selection of those are playable at any given time (unless you pay, or play a LOT)
This unfortunately leads to situations of running into someone you've never met before, and "getting owned" because you have literally no idea what you're up against, while they probably know your attacks and weaknesses inside out.
One of the most annoying factors for me, is range. Characters are roughly divided into melee and ranged. the former need to be more or less touching their target to attack, whereas the latter can attack by throwing something or other from some distance away. The biggest problem I find, is that, most likely in the interests of balance, all champions have roughly the same range as each other, with their special attacks, etc. This tends to lead to appealing to a DM to cut the player slack, and can become a device to cheating.
the various characters are nice, btu they seeem unbalanced. I've run across a few threads n the official dev forums (which, typically, the devs haven't officially responded to) that seem to share opinions of certain champions being either overpowered, or weak. So far, I've no reason to disagree with the above pretenses